Combination

Mixing Advil PM and Ibuprofen (Advil)

CombinationAnalgesic
Verdict

Caution · Pain reliever twice

Advil PM and Advil both contain an NSAID pain reliever like ibuprofen. The doses add up, and past the label amount the risk of stomach bleeding and kidney strain goes up, more so with alcohol or on an empty stomach. The Advil label names taking another NSAID as one of the things that raises the chance of stomach bleeding.

  1. Take one of them, not both. Advil PM already holds a full dose of ibuprofen.
What “Caution” means

Can you take Advil PM with Advil?

Advil PM contains ibuprofen and diphenhydramine. Advil PM and Advil both contain an NSAID pain reliever like ibuprofen. The doses add up, and past the label amount the risk of stomach bleeding and kidney strain goes up, more so with alcohol or on an empty stomach. The Advil label names taking another NSAID as one of the things that raises the chance of stomach bleeding. MixSafe rates Advil PM with Advil as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Sources: the Drug Facts labels on DailyMed. Educational information, not medical advice.

What is in it

Advil PM
Ibuprofen + Diphenhydramine.

Pain reliever twice

Caution

Advil PM + Advil

What to do
  1. 01Take one of them, not both.Advil PM already holds a full dose of ibuprofen.
Signs it is happening
  1. Stomach pain that does not ease, black or bloody stools, or vomiting blood
Why this happens

Advil PM and Advil both contain an NSAID pain reliever like ibuprofen.

The doses add up, and past the label amount the risk of stomach bleeding and kidney strain goes up, more so with alcohol or on an empty stomach. The Advil label names taking another NSAID as one of the things that raises the chance of stomach bleeding.

Sources
Sources

Ingredient lists checked 2026-09-27. Formulas change and store brands differ, so the Drug Facts box on your own packet is the final word.

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