Index

Every combination we have data for

820 pairs across 41 substances, each with its own page, rating and sources. Within each card the most concerning combinations come first.

Psychedelic

10 substances

LSD

40 pairs

1 dangerous · 1 unsafe · 7 caution

Mushrooms

40 pairs

1 dangerous · 1 unsafe · 5 caution

DMT

40 pairs

1 dangerous · 1 unsafe · 5 caution

Mescaline

40 pairs

2 dangerous · 1 unsafe · 13 caution

DOx

40 pairs

2 dangerous · 6 unsafe · 13 caution

NBOMes

40 pairs

3 dangerous · 5 unsafe · 12 caution

2C-x

40 pairs

2 dangerous · 1 unsafe · 12 caution

2C-T-x

40 pairs

3 dangerous · 5 unsafe · 12 caution

5-MeO-xxT

40 pairs

4 dangerous · 5 unsafe · 10 caution

AMT

40 pairs

17 dangerous · 6 caution · 5 low / synergy

Dissociative

5 substances

Ketamine

40 pairs

10 dangerous · 7 caution · 16 low / synergy

MXE

40 pairs

12 dangerous · 2 unsafe · 12 caution

DXM

40 pairs

15 dangerous · 10 unsafe · 3 caution

Nitrous Oxide

40 pairs

11 caution · 20 low / synergy · 1 low / decrease

PCP

40 pairs

8 dangerous · 8 unsafe · 11 caution

Stimulant

6 substances

Amphetamines

40 pairs

3 dangerous · 7 unsafe · 23 caution

Methamphetamine

40 pairs

3 dangerous · 15 unsafe · 15 caution

Cocaine

40 pairs

7 dangerous · 11 unsafe · 15 caution

Caffeine

40 pairs

1 unsafe · 12 caution · 1 low / synergy

Mephedrone

40 pairs

6 dangerous · 1 unsafe · 25 caution

Nicotine

40 pairs

4 caution · 3 low / synergy · 33 low / no synergy

Empathogen

1 substance

MDMA

40 pairs

6 dangerous · 4 unsafe · 12 caution

Depressant

6 substances

Alcohol

40 pairs

12 dangerous · 5 unsafe · 10 caution

Cannabis

40 pairs

14 caution · 20 low / synergy · 1 low / decrease

Benzodiazepines

40 pairs

9 dangerous · 3 unsafe · 4 caution

GHB / GBL

40 pairs

15 dangerous · 8 caution · 2 low / synergy

Pregabalin

40 pairs

9 dangerous · 10 unsafe · 13 caution

Melatonin

40 pairs

4 caution · 5 low / synergy · 31 low / no synergy

Deliriant

1 substance

Diphenhydramine

40 pairs

8 dangerous · 11 unsafe · 17 caution

Opioid

7 substances

Opioids

40 pairs

13 dangerous · 3 unsafe · 8 caution

Fentanyl

40 pairs

12 dangerous · 4 unsafe · 6 caution

Kratom

40 pairs

9 dangerous · 6 unsafe · 8 caution

Buprenorphine

40 pairs

7 dangerous · 7 unsafe · 8 caution

Methadone

40 pairs

12 dangerous · 4 unsafe · 7 caution

Codeine

40 pairs

12 dangerous · 3 unsafe · 9 caution

Tramadol

40 pairs

22 dangerous · 11 unsafe · 3 caution

Antidepressant

2 substances

SSRIs

40 pairs

5 dangerous · 1 unsafe · 9 caution

MAOIs

40 pairs

12 dangerous · 3 unsafe · 13 caution

Other

1 substance

Lithium

40 pairs

15 dangerous · 1 unsafe · 13 caution

Analgesic

2 substances

Acetaminophen

40 pairs

4 caution · 36 low / no synergy

Ibuprofen

40 pairs

1 unsafe · 3 caution · 36 low / no synergy