Mixing GHB / GBL (liquid G) and Xylazine (tranq)
Dangerous
Two sedatives with almost no margin, and naloxone reverses neither.
Do this
Do not combine. Put anyone who won't wake on their side so they cannot choke on vomit.
Where the risk isTap for why
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means
High risk of death or life-changing injury. Do not combine.
How the ratings workThe longer explanation
Two sedatives with very little room between a working dose and unconsciousness, acting on different receptors so neither limit helps, and naloxone reverses neither. Vomiting while unrousable is how this usually kills.
Sources (3)
- What You Should Know About Xylazine. CDCcdc.gov
- Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
- Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
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Other names
- GHB / GBL
- ghb, gbl, liquid ecstasy, 1,4-butanediol, bdo, 1,4-bd
- Xylazine
- tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine
- Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither
Also searched asliquid G and tranq, ghb and tranq, liquid G and tranq dope, ghb and tranq dope
Related combinations
GHB / GBL withWhat not to mix with GHB / GBL →
Xylazine with
All combinations →- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- ZolpidemDangerous
- PregabalinDangerous
Can you mix GHB / GBL (liquid G) and Xylazine (tranq)?
MixSafe rates mixing GHB / GBL and Xylazine as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.