Mixing MXE and Xylazine (tranq)

Q: How dangerous is MXE with Xylazine?

Dangerous: High risk of death or life-changing injury. Do not combine.

Q: Is it safe to mix MXE and tranq?

MixSafe lists tranq under Xylazine. That combination is rated "Dangerous". MXE is a ketamine-like dissociative, and ketamine with xylazine is how animals are anaesthetised for surgery: deep unconsciousness, slowed breathing and a slow heart, with nothing naloxone can reverse.

Dangerous

Close to the ketamine-xylazine mix vets use to anaesthetise animals.

Do this

Do not combine. Put anyone who won't wake on their side and call for help.

Where the risk isTap for why

In an emergency, call 911911 Never Use Alone Poison Control

What to do

Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.

What “Dangerous” means

High risk of death or life-changing injury. Do not combine.

How the ratings work

The longer explanation

MXE is a ketamine-like dissociative, and ketamine with xylazine is how animals are anaesthetised for surgery: deep unconsciousness, slowed breathing and a slow heart, with nothing naloxone can reverse.

Sources (2)

Sotoudeh et al. Optimisation of ketamine-xylazine anaesthetic dose in rats. Vet Med Sci. 2022pmc.ncbi.nlm.nih.gov
Ruiz-Colón K et al. Xylazine intoxication in humans. Forensic Sci Int. 2014sciencedirect.com

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Other names

MXE: methoxetamine
Xylazine: tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine; Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither

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Related combinations

MXE with

What not to mix with MXE →

Xylazine with

What not to mix with Xylazine →

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Can you mix MXE and Xylazine (tranq)?

MixSafe rates mixing MXE and Xylazine as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.