Substance
What not to mix with MXE
Dissociative
Also calledmethoxetamine
Summary
MXE is checked against 40 other substances — 12 dangerous, 2 unsafe and 12 caution.
Dangerous
12- MXE and AlcoholTogether they cause memory loss, vomiting and a severe loss of coordination. Do not combine.
- MXE and AMTHigh risk of death or life-changing injury. Do not combine.
- MXE and BuprenorphineMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- MXE and CodeineMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- MXE and DiphenhydramineThis risks serotonin syndrome and sudden unconsciousness, and MXE can push diphenhydramine into delirium. Do not combine at recreational doses. If…
- MXE and FentanylMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- MXE and GHB / GBLBoth wreck coordination and can cause vomiting and unconsciousness. Do not combine. If someone passes out, put them on their side so they cannot…
- MXE and KratomMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- MXE and LithiumLithium can set off serotonin syndrome with serotonin-acting drugs, and MXE is one. Do not combine.
- MXE and MethadoneMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- MXE and OpioidsMXE can make the opioid hit harder. Do not combine. Keep naloxone nearby.
- MXE and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
2Caution
12- MXE and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- MXE and AmphetaminesTogether they can race the heart, spike blood pressure, and tip into mania. Take less of each than usual, and do not use alone.
- MXE and BenzodiazepinesEach makes the other stronger, so high doses can knock you out without warning. Take less of each than usual, and do not use alone. If someone passes…
- MXE and CocaineTogether they tip into mania much more easily, especially without sleep. Take less of each than usual, and do not use alone.
- MXE and DOxMXE makes DOx stronger, which can be unpleasantly intense. Take less of each than usual, and do not use alone.
- MXE and MDMATaken at the same time they have caused risky serotonin reactions. Do not take them together.
- MXE and MephedroneThe stimulant hides how dissociated you are, which tempts redosing, and both strain the heart. Take less of each than usual, and do not use alone.
- MXE and MethamphetamineTogether they can race the heart, spike blood pressure, and tip into mania. Take less of each than usual, and do not use alone.
- MXE and NBOMesMXE makes NBOMes stronger, which can be unpleasantly intense. Take less of each than usual, and do not use alone.
- MXE and PCPThere are no reports on this combination. Take less of each than usual, and do not use alone.
- MXE and PregabalinEach can make the other's nausea, dizziness and blackouts worse, and more than low doses raise the risk of a seizure. Take less of each than usual…
- MXE and SSRIsDepending on the SSRI, this can be unpredictable. Take less MXE than usual, and do not use alone.
Low / synergy
9Low / no synergy
5Checking more than one?
This page rates MXE against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open MXE in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.