Substance
What not to mix with Ketamine
Dissociative
Also calledket, special k, kitty, kittens
Summary
Ketamine is checked against 40 other substances — 10 dangerous and 7 caution.
Dangerous
10- Ketamine and AlcoholBoth substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence…
- Ketamine and BuprenorphineBoth substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit…
- Ketamine and CodeineBoth substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit…
- Ketamine and DiphenhydramineBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Ketamine and FentanylBoth substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit…
- Ketamine and GHB / GBLBoth substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a…
- Ketamine and KratomBoth substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit…
- Ketamine and MethadoneBoth substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit…
- Ketamine and OpioidsBoth substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit…
- Ketamine and TramadolHigh risk of death or life-changing injury. Do not combine.
Caution
7- Ketamine and AmphetaminesNo unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this…
- Ketamine and BenzodiazepinesBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Ketamine and CocaineNo unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this…
- Ketamine and MAOIsMAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there…
- Ketamine and MephedroneThe stimulant masks how dissociated you are, which is how people redose ketamine past the point they intended.
- Ketamine and MethamphetamineNo unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this…
- Ketamine and PregabalinPregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution…
Low / synergy
16Low / no synergy
7Checking more than one?
This page rates Ketamine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Ketamine in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.