Substance
What not to mix with Ketamine (ket)
Dissociative
Also calledket, special k, kitty, kittens, ketty, ketalar
Summary
Ketamine is checked against 40 other substances — 10 dangerous and 7 caution.
Dangerous
10- Ketamine and AlcoholBoth knock out coordination, and together vomiting and passing out are very likely. Do not combine. If someone passes out, put them on their side so…
- Ketamine and BuprenorphineTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Ketamine and CodeineTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Ketamine and DiphenhydramineEach makes the other stronger: people pass out without warning, and ketamine can push diphenhydramine into delirium. Do not combine at recreational…
- Ketamine and FentanylTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Ketamine and GHB / GBLBoth wreck coordination and can cause vomiting and unconsciousness. Do not combine. If someone passes out, put them on their side so they cannot…
- Ketamine and KratomTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Ketamine and MethadoneTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Ketamine and OpioidsTogether they can cause vomiting and unconsciousness. Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.
- Ketamine and TramadolHigh risk of death or life-changing injury. Do not combine.
Caution
7- Ketamine and AmphetaminesLikely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.
- Ketamine and BenzodiazepinesEach makes the other stronger, so high doses can knock you out without warning. Take less of each than usual, and do not use alone. If someone passes…
- Ketamine and CocaineLikely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.
- Ketamine and MAOIsMAOIs appear to make ketamine stronger, and there are bad reports with some MAOIs. Take less ketamine than usual, and do not use alone.
- Ketamine and MephedroneThe stimulant hides how dissociated you are, so people take more ketamine than they meant to. Decide your ketamine dose in advance and do not redose.
- Ketamine and MethamphetamineLikely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.
- Ketamine and PregabalinEach can make the other's nausea, dizziness and blackouts worse, and higher doses raise the risk of a seizure. Take less of each than usual, and do…
Low / synergy
16Low / no synergy
7Checking more than one?
This page rates Ketamine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Ketamine in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.