Substance
What not to mix with PCP (angel dust)
Dissociative
Also calledphencyclidine, angel dust, angeldust, wet, sherm
Summary
PCP is checked against 40 other substances — 8 dangerous, 8 unsafe and 11 caution.
Dangerous
8- PCP and 2C-T-xHigh risk of death or life-changing injury. Do not combine.
- PCP and 5-MeO-xxTHigh risk of death or life-changing injury. Do not combine.
- PCP and AMTHigh risk of death or life-changing injury. Do not combine.
- PCP and DiphenhydramineTogether they cause heavy delirium and memory loss, often with behaviour you will not remember. Do not combine.
- PCP and DXMHigh risk of death or life-changing injury. Do not combine.
- PCP and GHB / GBLLittle is known about this pair, and PCP interacts unpredictably. Do not combine.
- PCP and MAOIsThis combination is barely documented. Do not combine.
- PCP and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
8- PCP and AlcoholLittle is known about this pair, and PCP interacts unpredictably. Avoid this combination.
- PCP and AmphetaminesThis combination easily tips into mania. Avoid it.
- PCP and BenzodiazepinesEach makes the other stronger, so people pass out without warning and black out. Avoid this combination. If someone passes out, put them on their…
- PCP and CocaineThis combination easily tips into mania. Avoid it.
- PCP and DOxLittle is known about this pair, and PCP interacts unpredictably. Avoid this combination.
- PCP and MDMAThis combination easily tips into mania. Avoid it.
- PCP and MethamphetamineThis combination easily tips into mania. Avoid it.
- PCP and SSRIsLittle is known about this pair, and PCP interacts unpredictably. Avoid this combination.
Caution
11- PCP and BuprenorphinePCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
- PCP and CaffeineLittle is known about this pair, and PCP interacts unpredictably. Take less of each than usual, and do not use alone.
- PCP and CodeinePCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
- PCP and FentanylPCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
- PCP and KratomPCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
- PCP and LithiumLithium lowers the seizure threshold, and how dissociatives interact with it is poorly reported. Take less PCP than usual, and do not use alone.
- PCP and MephedroneUnpredictable, with more heart strain and worse judgement. Take less of each than usual, and do not use alone.
- PCP and MethadonePCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
- PCP and MXEThere are no reports on this combination. Take less of each than usual, and do not use alone.
- PCP and OpioidsPCP can lower your opioid tolerance, making an overdose more likely. Take less opioid than usual, do not use alone, and keep naloxone nearby.
- PCP and PregabalinTogether they add sedation and clumsiness, and blackouts become much more likely. Take less of each than usual, and do not use alone.
Low / synergy
9Low / no synergy
4Checking more than one?
This page rates PCP against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open PCP in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.