Substance
What not to mix with PCP
Dissociative
Also calledphencyclidine, angel dust, angeldust, wet, sherm
Summary
PCP is checked against 40 other substances — 8 dangerous, 8 unsafe and 11 caution.
Dangerous
8- PCP and 2C-T-xHigh risk of death or life-changing injury. Do not combine.
- PCP and 5-MeO-xxTHigh risk of death or life-changing injury. Do not combine.
- PCP and AMTHigh risk of death or life-changing injury. Do not combine.
- PCP and DiphenhydramineConsistent with diphenhydramine's rating against other dissociatives: strongly additive delirium, confusion and amnesia, with a high chance of…
- PCP and DXMHigh risk of death or life-changing injury. Do not combine.
- PCP and GHB / GBLDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- PCP and MAOIsThis combination is very poorly explored
- PCP and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
8- PCP and AlcoholDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- PCP and AmphetaminesThis combination can easily lead to hypermanic states
- PCP and BenzodiazepinesBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- PCP and CocaineThis combination can easily lead to hypermanic states
- PCP and DOxDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- PCP and MDMAThis combination can easily lead to hypermanic states
- PCP and MethamphetamineThis combination can easily lead to hypermanic states
- PCP and SSRIsDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Caution
11- PCP and BuprenorphinePCP can reduce opioid tolerance, increasing the risk of overdose
- PCP and CaffeineDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- PCP and CodeinePCP can reduce opioid tolerance, increasing the risk of overdose
- PCP and FentanylPCP can reduce opioid tolerance, increasing the risk of overdose
- PCP and KratomPCP can reduce opioid tolerance, increasing the risk of overdose
- PCP and LithiumBoth affect neuronal excitability and lithium narrows the seizure threshold. Dissociative interactions with lithium are inconsistently reported…
- PCP and MephedroneStimulant against dissociative — unpredictable, with additive cardiovascular strain and impaired judgement.
- PCP and MethadonePCP can reduce opioid tolerance, increasing the risk of overdose
- PCP and MXEThere are no reports available about this combination
- PCP and OpioidsPCP can reduce opioid tolerance, increasing the risk of overdose
- PCP and PregabalinAdditive sedation, disinhibition and impaired coordination, with a substantially raised risk of blackout.
Low / synergy
9Low / no synergy
4Checking more than one?
This page rates PCP against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open PCP in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.