Mixing Diphenhydramine (Benadryl) and PCP (angel dust)
Dangerous
Together they cause heavy delirium and memory loss, often with behaviour you will not remember. Do not combine.
Consistent with diphenhydramine's rating against other dissociatives: strongly additive delirium, confusion and amnesia, with a high chance of behaviour that neither substance alone would produce and no reliable memory of it.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Headspace vs physical riskWhat to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
Can you mix Diphenhydramine (Benadryl) and PCP (angel dust)?
MixSafe rates mixing Diphenhydramine and PCP as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom, doxylamine
- PCP also called
- phencyclidine, angel dust, angeldust, wet, sherm
- Serotonin Syndrome: Mechanisms, Diagnosis, High-Risk Interactions. https://psychopharmacologyinstitute.com/publication/serotonin-syndrome-mechanisms-diagnosis-high-risk-interactions-and-management/
- Diphenhydramine interaction profile. Drugs.com. https://www.drugs.com/drug-interactions/melatonin.html
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.