Mixing Alcohol and Diphenhydramine
- Alcohol also called
- booze, beer, wine, liquor, ethanol, etoh
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom
Dangerous
The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackouts and memory loss are significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. Alcohol may also increase the deliriant effects of diphenhydramine. It should also be noted if the individual consuming alcohol typically has a flushing response to alcohol, diphenhydramine may reduce the reaction and mask some of the effects of the alcohol.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Can you mix Alcohol and Diphenhydramine?
High risk of death or life-changing injury. Do not combine.
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.