Substance
What not to mix with Alcohol
Depressant
Also calledbooze, beer, wine, liquor, ethanol, etoh
Summary
Alcohol is checked against 40 other substances — 12 dangerous, 5 unsafe and 10 caution.
Dangerous
12- Alcohol and BenzodiazepinesEthanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very…
- Alcohol and CodeineThe lean pairing, and the reason it kills people who thought they were being moderate. Codeine's conversion to morphine varies enormously between…
- Alcohol and DiphenhydramineThe two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side…
- Alcohol and DXMBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the…
- Alcohol and FentanylThe active dose of fentanyl is measured in micrograms, and illicit powder or pressed pills are almost never mixed evenly — two pills from the same…
- Alcohol and GHB / GBLEven in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration…
- Alcohol and KetamineBoth substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence…
- Alcohol and MethadoneMethadone's half-life runs anywhere from 8 to 59 hours and it accumulates in tissue, so the dose you took is still substantially present long after…
- Alcohol and MXEThere is a high risk of memory loss, vomiting and severe ataxia from this combination.
- Alcohol and OpioidsBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the…
- Alcohol and PregabalinGabapentinoids cause respiratory depression in their own right, and the FDA's review found that risk concentrated almost entirely in people also…
- Alcohol and TramadolHeavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of…
Unsafe
5- Alcohol and BuprenorphineBuprenorphine's partial agonism puts a ceiling on its own respiratory depression, and alcohol goes around that ceiling through a different receptor…
- Alcohol and CocaineCocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater…
- Alcohol and KratomRated below heroin + alcohol, and the difference is real rather than cosmetic. Mitragynine is a partial mu-agonist that barely signals through the…
- Alcohol and MAOIsTyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.
- Alcohol and PCPDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Caution
10- Alcohol and AcetaminophenAlcohol induces CYP2E1 and depletes the liver's glutathione, so more acetaminophen is converted to NAPQI, the metabolite that causes liver injury…
- Alcohol and AmphetaminesDrinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This…
- Alcohol and AMTaMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable
- Alcohol and IbuprofenBoth irritate the stomach lining and both stress the kidneys. Together they raise the risk of gastrointestinal bleeding and ulcers, and of acute…
- Alcohol and LithiumDehydration from drinking concentrates lithium and can raise blood levels toward the toxic range, and the two are additively impairing. Vomiting or…
- Alcohol and MDMAThe combination of MDMA and alcohol may increase strain on the cardiovascular system and lead to increased alcohol consumption. MDMA may also impair…
- Alcohol and MephedroneAlcohol enhances mephedrone's stimulant effect and markedly increases the urge to redose. Animal work also shows the combination produces broader…
- Alcohol and MethamphetamineAlcohol's sedation is masked, so people drink considerably more than they otherwise would and remember less of it. Both strain the heart. The…
- Alcohol and Nitrous OxideBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
- Alcohol and SSRIsAlcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system…
Low / synergy
3Low / decrease
9Low / no synergy
1Checking more than one?
This page rates Alcohol against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Alcohol in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.