Substance
What not to mix with Alcohol
Depressant
Also calledalc, booze, beer, wine, liquor, ethanol
Summary
Alcohol is checked against 40 other substances — 12 dangerous, 5 unsafe and 10 caution.
Dangerous
12- Alcohol and BenzodiazepinesEach makes the other much stronger, fast and unpredictably, so people pass out and black out. Do not combine. If someone passes out, put them on…
- Alcohol and CodeineHow strong codeine is varies hugely from person to person, and alcohol adds its own slowed breathing on top. Do not combine. Keep naloxone nearby.
- Alcohol and DiphenhydramineAt everyday doses, studies find diphenhydramine makes alcohol's hit to coordination and reaction time much worse, and you will not feel how impaired…
- Alcohol and DXMEach makes the other stronger: you can lose coordination, pass out without warning, and have trouble breathing. Do not combine, and never above the…
- Alcohol and FentanylFentanyl doses vary wildly even within one batch, and alcohol removes whatever margin is left. Do not combine. If you use anyway: never in the same…
- Alcohol and GHB / GBLEven small amounts of each together can quickly cause memory loss, collapse and unconsciousness. Do not combine. If someone passes out, put them on…
- Alcohol and KetamineBoth knock out coordination, and together vomiting and passing out are very likely. Do not combine. If someone passes out, put them on their side so…
- Alcohol and MethadoneMethadone stays in your body long after you stop feeling it, so drinking adds to a load you cannot feel. Do not combine, especially in the first two…
- Alcohol and MXETogether they cause memory loss, vomiting and a severe loss of coordination. Do not combine.
- Alcohol and OpioidsEach makes the other stronger, and together they can knock you out without warning. Do not combine. Keep naloxone nearby, and put anyone who passes…
- Alcohol and PregabalinTogether they can stop your breathing, and pregabalin's slow start tempts people to take more before it peaks. Do not combine. Do not redose, and put…
- Alcohol and TramadolBoth are heavy depressants: together they can cause seizures and sudden unconsciousness. Do not combine. If someone passes out, put them on their…
Unsafe
5- Alcohol and BuprenorphineBuprenorphine's ceiling on slowed breathing does not protect you from alcohol; most deaths on buprenorphine involve alcohol or benzos. Avoid this…
- Alcohol and CocaineCocaine hides how drunk you are, so people drink more, and the two together may be harder on the heart than cocaine alone. Avoid this combination. If…
- Alcohol and KratomKratom's ceiling on slowed breathing does not hold once alcohol is involved; heavy sedation and choking on vomit are the usual danger. Avoid this…
- Alcohol and MAOIsMany drinks contain tyramine, which with an MAOI can push blood pressure dangerously high. Avoid this combination.
- Alcohol and PCPLittle is known about this pair, and PCP interacts unpredictably. Avoid this combination.
Caution
10- Alcohol and AcetaminophenAlcohol makes acetaminophen harder on the liver, most of all for regular drinkers and while alcohol is clearing. Do not take repeated doses while…
- Alcohol and AmphetaminesAmphetamines hide how drunk you are, so people drink far more than they mean to. If you mix them, set an hourly drink limit before you start and…
- Alcohol and AMTBoth act broadly on the brain, so the mix is unpredictable. Take less of each than usual, and do not use alone.
- Alcohol and IbuprofenBoth are hard on the stomach and kidneys, raising the risk of bleeding and kidney injury. Avoid regular use together, and do not take ibuprofen when…
- Alcohol and LithiumDehydration from drinking can push lithium toward toxic levels, worse with vomiting or sweating. Drink less, and keep up water.
- Alcohol and MDMAMDMA hides how drunk you are, and together they strain the heart and make overheating and dehydration more likely. Keep drinks few, sip water, and…
- Alcohol and MephedroneAlcohol makes mephedrone feel stronger and makes you want more of both, with worse judgement about each. Decide the total for the night in advance.
- Alcohol and MethamphetamineMeth hides how drunk you are, so people drink much more across a very long session. Set a drink limit before you start.
- Alcohol and Nitrous OxideEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual. If someone passes out, put them on…
- Alcohol and SSRIsAlcohol can hit harder than usual on an SSRI, dulling judgement and coordination more. Drink less than you normally would.
Low / synergy
3Low / decrease
9Low / no synergy
1Checking more than one?
This page rates Alcohol against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Alcohol in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.