Substance
What not to mix with Benzodiazepines (Xanax)
DepressantDrug class
Also calledbenzodiazepine, benzos, benzo, xanax, alprazolam, valium
Summary
Benzodiazepines is checked against 40 other substances — 9 dangerous, 3 unsafe and 4 caution.
Dangerous
9- Benzodiazepines and AlcoholEach makes the other much stronger, fast and unpredictably, so people pass out and black out. Do not combine. If someone passes out, put them on…
- Benzodiazepines and CodeineTogether they slow breathing, and codeine's strength is unpredictable. Do not combine. Keep naloxone nearby.
- Benzodiazepines and FentanylThe deadliest pairing in current overdose data: people simply stop breathing, often silently. Do not combine. If you use anyway, never alone, and…
- Benzodiazepines and GHB / GBLEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. If someone passes out, put them on their side…
- Benzodiazepines and KratomThe riskiest kratom combination: together they get past kratom's ceiling on slowed breathing, and kratom can peak late. Do not combine.
- Benzodiazepines and MethadoneTogether they slow breathing, on top of methadone's long, unfelt tail. Do not combine, especially early in methadone treatment.
- Benzodiazepines and OpioidsTogether they can slow or stop breathing and knock you out very quickly. Do not combine. Keep naloxone nearby, and put anyone who passes out on their…
- Benzodiazepines and PregabalinTogether they can stop your breathing, and both cause blackouts, so people redose without remembering the first dose. Do not combine.
- Benzodiazepines and TramadolTogether they can slow breathing and knock you out. Do not combine. If someone passes out, put them on their side so they cannot choke on vomit.
Unsafe
3- Benzodiazepines and BuprenorphineThe main cause of death in people taking buprenorphine. Avoid recreational benzos on top, and do not stop a prescribed one abruptly.
- Benzodiazepines and DiphenhydramineEach makes the other stronger, so people pass out without warning and black out. Avoid this combination beyond low medical doses. If someone passes…
- Benzodiazepines and PCPEach makes the other stronger, so people pass out without warning and black out. Avoid this combination. If someone passes out, put them on their…
Caution
4- Benzodiazepines and DXMEach makes the other stronger, so high doses can knock you out without warning. Take less of each than usual, and do not use alone. If someone passes…
- Benzodiazepines and KetamineEach makes the other stronger, so high doses can knock you out without warning. Take less of each than usual, and do not use alone. If someone passes…
- Benzodiazepines and MelatoninTogether they add drowsiness, confusion and clumsiness, which raises the risk of falls. Take less than usual, and add nothing else sedating.
- Benzodiazepines and MXEEach makes the other stronger, so high doses can knock you out without warning. Take less of each than usual, and do not use alone. If someone passes…
Low / synergy
1Low / decrease
18Low / no synergy
5Checking more than one?
This page rates Benzodiazepines against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Benzodiazepines in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.