Mixing Benzodiazepines (Xanax) and SSRIs (antidepressants)
Low risk, no synergy
Neither substance is expected to meaningfully change the other. Both still carry their own individual risks.
Can you mix Benzodiazepines (Xanax) and SSRIs (antidepressants)?
MixSafe rates mixing Benzodiazepines and SSRIs as "Low risk, no synergy" — neither substance is expected to meaningfully change the other. Both still carry their own individual risks. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.