Combination
Mixing Benzodiazepines and Pregabalin
DepressantDepressant
- Benzodiazepines also called
- benzodiazepine, benzos, benzo, xanax, alprazolam, valium
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba
Verdict
Dangerous
Additive respiratory depression between two CNS depressants, and a combination that appears repeatedly in overdose death reports. Both also cause blackouts, so the usual failure mode is redosing with no memory of the earlier dose.
Risk / Physical
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Can you mix Benzodiazepines and Pregabalin?
High risk of death or life-changing injury. Do not combine.
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Benzodiazepines withWhat not to mix with Benzodiazepines →
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.