Mixing GHB / GBL and Pregabalin (Lyrica)
Dangerous
Each makes the other much stronger: blackouts, unconsciousness and seizures all become more likely. Do not combine. If someone passes out, put them on their side.
The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackout and memory loss risk is significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. There is an increased risk of seizures from this combination.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskWhat to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
Can you mix GHB / GBL and Pregabalin (Lyrica)?
MixSafe rates mixing GHB / GBL and Pregabalin as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- GHB / GBL also called
- ghb, gbl, liquid ecstasy, 1,4-butanediol, bdo, 1,4-bd
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.