Substance
What not to mix with GHB / GBL
Depressant
Also calledghb, gbl, liquid ecstasy, 1,4-butanediol, bdo, 1,4-bd
Summary
GHB / GBL is checked against 40 other substances — 15 dangerous and 8 caution.
Dangerous
15- GHB / GBL and AlcoholEven small amounts of each together can quickly cause memory loss, collapse and unconsciousness. Do not combine. If someone passes out, put them on…
- GHB / GBL and BenzodiazepinesEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. If someone passes out, put them on their side…
- GHB / GBL and BuprenorphineEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. Keep naloxone nearby, and put anyone who…
- GHB / GBL and CodeineEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. Keep naloxone nearby, and put anyone who…
- GHB / GBL and DiphenhydramineEach makes the other much stronger, raising the risk of memory loss, collapse and unconsciousness. Do not combine. If someone passes out, put them on…
- GHB / GBL and DXMBoth wreck coordination and can cause vomiting and unconsciousness, and together they are hard to predict. Do not combine. If someone passes out, put…
- GHB / GBL and FentanylBoth have almost no margin, and naloxone reverses the fentanyl but does nothing for the GHB. Do not combine.
- GHB / GBL and KetamineBoth wreck coordination and can cause vomiting and unconsciousness. Do not combine. If someone passes out, put them on their side so they cannot…
- GHB / GBL and KratomGHB is steep enough on its own; an opioid removes the margin, and choking on vomit is how this kills. Do not combine. Put anyone who passes out on…
- GHB / GBL and MethadoneEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. Keep naloxone nearby, and put anyone who…
- GHB / GBL and MXEBoth wreck coordination and can cause vomiting and unconsciousness. Do not combine. If someone passes out, put them on their side so they cannot…
- GHB / GBL and OpioidsEach makes the other much stronger, fast and unpredictably, so people pass out quickly. Do not combine. Keep naloxone nearby, and put anyone who…
- GHB / GBL and PCPLittle is known about this pair, and PCP interacts unpredictably. Do not combine.
- GHB / GBL and PregabalinEach makes the other much stronger: blackouts, unconsciousness and seizures all become more likely. Do not combine. If someone passes out, put them…
- GHB / GBL and TramadolTogether they can slow breathing dangerously. Do not combine.
Caution
8- GHB / GBL and AmphetaminesThe stimulant hides how sedated you are; if it wears off first, the GHB can stop your breathing. Take less of each than usual, and do not use alone.
- GHB / GBL and CocaineEach hides the other; whichever wears off first leaves you with a dangerous amount of the other. Take less of each than usual, and do not use alone.
- GHB / GBL and LithiumTogether they add sedation, and dehydration can raise lithium levels; GHB's narrow dose range is the main danger. Take less GHB than usual, and do…
- GHB / GBL and MDMAA lot of GHB can overwhelm you as the MDMA wears off. Take less GHB than usual, and do not use alone.
- GHB / GBL and MelatoninMelatonin adds sedation and blurs the early signs of going under on a drug with almost no margin already. Take less GHB than usual, and do not use…
- GHB / GBL and MephedroneEach hides the other; whichever wears off first can leave you overdosed on the other. Both strain the heart. Take less of each than usual, and do not…
- GHB / GBL and MethamphetamineThe stimulant hides how sedated you are; if it wears off first, the GHB can stop your breathing. Take less of each than usual, and do not use alone.
- GHB / GBL and Nitrous OxideEach makes the other stronger, so you can lose balance or pass out without warning. Take less of each than usual, and do not use alone.
Low / synergy
2Low / decrease
10Low / no synergy
5Checking more than one?
This page rates GHB / GBL against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open GHB / GBL in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.