Substance
What not to mix with GHB / GBL
Depressant
Also calledghb, gbl, liquid ecstasy
Summary
GHB / GBL is checked against 40 other substances — 15 dangerous and 8 caution.
Dangerous
15- GHB / GBL and AlcoholEven in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration…
- GHB / GBL and BenzodiazepinesThe two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is…
- GHB / GBL and BuprenorphineThe two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is…
- GHB / GBL and CodeineThe two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is…
- GHB / GBL and DiphenhydramineBoth substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and…
- GHB / GBL and DXMBoth substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is…
- GHB / GBL and FentanylTwo substances with almost no margin between a working dose and an unrousable one, acting on different receptors so neither ceiling helps. Naloxone…
- GHB / GBL and KetamineBoth substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a…
- GHB / GBL and KratomGHB's dose-response curve is steep enough to be dangerous on its own; an opioid on top removes the margin. Unrousable sedation with vomiting is the…
- GHB / GBL and MethadoneThe two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is…
- GHB / GBL and MXEBoth substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is…
- GHB / GBL and OpioidsThe two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is…
- GHB / GBL and PCPDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- GHB / GBL and PregabalinThe two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side…
- GHB / GBL and TramadolThe sedative effects of this combination can lead to dangerous respiratory depression.
Caution
8- GHB / GBL and AmphetaminesStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome…
- GHB / GBL and CocaineStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome…
- GHB / GBL and LithiumAdditive sedation and impairment, plus dehydration risk affecting lithium levels. GHB's narrow dose window is the dominant danger here.
- GHB / GBL and MDMALarge amounts of GHB/GBL may overwhelm the effects of MDMA on the comedown.
- GHB / GBL and MelatoninAdditive sedation with a drug that already has a very narrow gap between a recreational dose and unconsciousness. Melatonin blurs the early warning…
- GHB / GBL and MephedroneBoth can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction. Both substances…
- GHB / GBL and MethamphetamineStimulants increase respiration rate allowing for a higher dose of sedatives than normal. If the stimulant wears off first the opiate may overcome…
- GHB / GBL and Nitrous OxideBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While…
Low / synergy
2Low / decrease
10Low / no synergy
5Checking more than one?
This page rates GHB / GBL against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open GHB / GBL in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.