Substance
What not to mix with Melatonin
Depressant
Also calledsleep hormone, circadin
Summary
Melatonin is checked against 40 other substances — 4 caution.
Caution
4- Melatonin and BenzodiazepinesAdditive CNS depression — increased drowsiness, confusion, impaired coordination and memory. The combination is common and rarely dangerous at normal…
- Melatonin and GHB / GBLAdditive sedation with a drug that already has a very narrow gap between a recreational dose and unconsciousness. Melatonin blurs the early warning…
- Melatonin and OpioidsAdditive sedation on top of an opioid's respiratory depression. Melatonin is not the main risk in this stack, but it deepens sedation and makes an…
- Melatonin and TramadolAdditive sedation, plus tramadol's own serotonergic activity. Reported serotonin-syndrome cases involving melatonin are very rare, but tramadol is…
Low / synergy
5Low / no synergy
31Checking more than one?
This page rates Melatonin against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Melatonin in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.