Substance
What not to mix with Melatonin
Depressant
Also calledsleep hormone, circadin
Summary
Melatonin is checked against 40 other substances — 4 caution.
Caution
4- Melatonin and BenzodiazepinesTogether they add drowsiness, confusion and clumsiness, which raises the risk of falls. Take less than usual, and add nothing else sedating.
- Melatonin and GHB / GBLMelatonin adds sedation and blurs the early signs of going under on a drug with almost no margin already. Take less GHB than usual, and do not use…
- Melatonin and OpioidsMelatonin deepens the opioid's sedation and makes an overdose look like falling asleep. Do not use alone, and keep naloxone nearby.
- Melatonin and TramadolTogether they add sedation, and tramadol makes a rare serotonin reaction possible. Take less of each than usual.
Low / synergy
5Low / no synergy
31Checking more than one?
This page rates Melatonin against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Melatonin in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.