Mixing 7-OH and Melatonin

Q: How dangerous is 7-OH with Melatonin?

Caution: Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Caution

Melatonin deepens the opioid's sedation and makes an overdose look like falling asleep.

Do this

Do not use alone, and keep naloxone nearby.

Where the risk isTap for why

What “Caution” means

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

How the ratings work

The longer explanation

Melatonin deepens the opioid's sedation and makes an overdose look like falling asleep.

Sources (5)

Hill R et al. The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine. Br J Pharmacol. 2022pmc.ncbi.nlm.nih.gov
FDA recommends scheduling of 7-OH (7-hydroxymitragynine). HHS, July 2025hhs.gov
Melatonin Interactions Checker. Drugs.comdrugs.com
Melatonin + Xanax: Can You Take Them Together?drugs.com
Melatonin and SSRIsubiehealth.com

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Other names

7-OH: 7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs; Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
Melatonin: sleep hormone, circadin

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Related combinations

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Can you mix 7-OH and Melatonin?

MixSafe rates mixing 7-OH and Melatonin as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.