Mixing 7-OH and Cocaine (coke)

Dangerous

Cocaine hides how much the opioid is slowing you down, so you take more; when the cocaine wears off first, breathing can stop.

Do this

Do not combine. Keep naloxone nearby.

General answer for Opioids: nothing specific to these two is documented.

Where the risk isTap for why
In an emergency, call 911911Never Use AlonePoison Control
What to do
  • Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
  • Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
  • Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
  • Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
  • Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
  • Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means

High risk of death or life-changing injury. Do not combine.

How the ratings work
The longer explanation

Stimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.

Sources (1)

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Other names
7-OH
7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs
Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
Cocaine
coke, crack, blow, snow, yayo, yay
Also searched as7-oh and coke, 7-oh and crack
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Related combinations

7-OH withWhat not to mix with 7-OH →
Cocaine withWhat not to mix with Cocaine →
All combinations →

Can you mix 7-OH and Cocaine (coke)?

MixSafe rates mixing 7-OH and Cocaine as "Dangerous" — high risk of death or life-changing injury. Do not combine. No interaction specific to 7-OH and Cocaine is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.