Substance
What not to mix with Cocaine (coke)
Stimulant
Also calledcoke, crack, blow, snow, yayo, yay
Summary
Cocaine is checked against 40 other substances — 7 dangerous, 11 unsafe and 15 caution.
Dangerous
7- Cocaine and AMTHigh risk of death or life-changing injury. Do not combine.
- Cocaine and BuprenorphineCocaine hides how much the opioid is slowing you down, so you take more; when the cocaine wears off first, breathing can stop. Do not combine. Keep…
- Cocaine and CodeineCocaine hides how much the opioid is slowing you down, so you take more; when the cocaine wears off first, breathing can stop. Do not combine. Keep…
- Cocaine and KratomCocaine hides how much the opioid is slowing you down, so you take more; when the cocaine wears off first, breathing can stop. Do not combine. Keep…
- Cocaine and MAOIsThis combination is barely documented. Do not combine.
- Cocaine and OpioidsCocaine hides how much the opioid is slowing you down, so you take more; when the cocaine wears off first, breathing can stop. Do not combine. Keep…
- Cocaine and TramadolBoth raise the risk of a seizure, and together that risk adds up. Do not combine.
Unsafe
11- Cocaine and 2C-T-xBoth are strongly stimulating: together they can race the heart, spike blood pressure, and in extreme cases cause heart failure. Avoid this…
- Cocaine and 5-MeO-xxTStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating. Avoid this combination.
- Cocaine and AlcoholCocaine hides how drunk you are, so people drink more, and the two together may be harder on the heart than cocaine alone. Avoid this combination. If…
- Cocaine and DOxTogether they are heavy on the body and prone to thought loops, and coming down from the cocaine while the DOx is still going is very anxious. Avoid…
- Cocaine and DXMBoth raise heart rate, and panic on this mix has led to serious heart problems. Avoid this combination.
- Cocaine and FentanylCocaine hides how sedated you are; it wears off within the hour while fentanyl keeps working, and breathing can stop. Avoid this combination. Test…
- Cocaine and MethadoneBoth can disturb the heart's rhythm, and you would not feel it building. Avoid this combination.
- Cocaine and MethamphetamineTwo strong stimulants stack heart rate, blood pressure and body temperature, and meth outlasts every line of cocaine. Avoid this combination.
- Cocaine and NBOMesBoth are strongly stimulating: together they can race the heart, spike blood pressure, and in extreme cases cause heart failure. Avoid this…
- Cocaine and PCPThis combination easily tips into mania. Avoid it.
- Cocaine and PregabalinThis carries a real seizure risk, and if the cocaine wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
Caution
15- Cocaine and 2C-xStimulants make a trip more anxious and loop-prone, and the stimulation together can be uncomfortable. Take less of each than usual, and do not use…
- Cocaine and AmphetaminesTwo stimulants strain the heart, and cocaine blunts amphetamine anyway. Take less of each than usual, and do not use alone.
- Cocaine and CaffeineTwo stimulants can race the heart and spike blood pressure. Keep caffeine light.
- Cocaine and CannabisThe stimulant can make cannabis more anxious and loop-prone. Take less of each than usual.
- Cocaine and DiphenhydramineCocaine hides how sedated you are; if it wears off first, high doses of diphenhydramine can stop your breathing. Both strain the heart. Keep…
- Cocaine and DMTThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Cocaine and GHB / GBLEach hides the other; whichever wears off first leaves you with a dangerous amount of the other. Take less of each than usual, and do not use alone.
- Cocaine and KetamineLikely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.
- Cocaine and LSDThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Cocaine and MDMACocaine blunts MDMA and raises the risk of a heart attack. Take less of each than usual, and do not use alone.
- Cocaine and MephedroneStacking stimulants strains the heart far more than it adds to the high. Take less of each than usual, and decide the total for the night in advance.
- Cocaine and MescalinePsychedelics magnify a stimulant's focus and anxiety, making thought loops more likely. Take less of each than usual, and do not use alone.
- Cocaine and MushroomsThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Cocaine and MXETogether they tip into mania much more easily, especially without sleep. Take less of each than usual, and do not use alone.
- Cocaine and NicotineTogether they strain the heart much harder than either alone, and chain-smoking on cocaine is a big part of why people end up in hospital with chest…
Low / synergy
1Low / decrease
2Low / no synergy
4Checking more than one?
This page rates Cocaine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Cocaine in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.