Substance
What not to mix with Caffeine
Stimulant
Also calledcoffee, energy drink, espresso, pre-workout
Summary
Caffeine is checked against 40 other substances — 1 unsafe and 12 caution.
Unsafe
1Caution
12- Caffeine and AmphetaminesThis combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater…
- Caffeine and AMTHigh doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some…
- Caffeine and CocaineBoth stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.
- Caffeine and DiphenhydramineCaffeine as a stimulant may mask some negative side effects of DPH, leading to delusions of sobriety, which has additional concerns in states of…
- Caffeine and DOxHigh doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
- Caffeine and DXMHigh doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This…
- Caffeine and LithiumCaffeine increases renal lithium excretion, so heavy coffee or energy-drink use lowers blood lithium levels — and abruptly stopping caffeine can push…
- Caffeine and MDMACaffeine is not really necessary with MDMA and increases any neurotoxic effects from MDMA
- Caffeine and MephedroneThis combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and great…
- Caffeine and MethamphetamineThis combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater…
- Caffeine and NBOMesCaffeine can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle…
- Caffeine and PCPDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Low / synergy
1Low / decrease
1Low / no synergy
25Checking more than one?
This page rates Caffeine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Caffeine in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.