Substance
What not to mix with Methamphetamine (meth)
Stimulant
Also calledmeth, crystal, crystal meth, ice, tina, shard
Roughly twice as potent, and lasts three to four times as long
Summary
Methamphetamine is checked against 40 other substances — 3 dangerous, 15 unsafe and 15 caution.
Dangerous
3- Methamphetamine and AMTHigh risk of death or life-changing injury. Do not combine.
- Methamphetamine and MAOIsAn MAOI stops the body breaking down what meth releases, risking a blood-pressure crisis and serotonin syndrome for hours. Do not combine, and that…
- Methamphetamine and TramadolBoth raise the risk of a seizure, and together that risk adds up. Do not combine.
Unsafe
15- Methamphetamine and 2C-T-xStimulants make a trip more anxious and loop-prone, and together they can overwork the heart. Avoid this combination.
- Methamphetamine and 5-MeO-xxTStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating. Avoid this combination.
- Methamphetamine and BuprenorphineMeth hides how much the opioid is slowing you, and when it fades, everything you redosed hits at once, often as you fall asleep. Avoid this…
- Methamphetamine and CocaineTwo strong stimulants stack heart rate, blood pressure and body temperature, and meth outlasts every line of cocaine. Avoid this combination.
- Methamphetamine and CodeineMeth hides how much the opioid is slowing you, and when it fades, everything you redosed hits at once, often as you fall asleep. Avoid this…
- Methamphetamine and DOxTogether they are heavy on the body and prone to thought loops, and coming down from the amphetamine while the DOx is still going is very anxious…
- Methamphetamine and DXMBoth raise heart rate, and panic on this mix has led to serious heart problems. Avoid this combination.
- Methamphetamine and FentanylMeth hides the fentanyl for hours, so people redose it, and when the meth fades the whole load hits. Avoid this combination. If you use anyway, never…
- Methamphetamine and KratomMeth hides how much the opioid is slowing you, and when it fades, everything you redosed hits at once, often as you fall asleep. Avoid this…
- Methamphetamine and MDMABoth hit the same brain cells, and meth keeps up the heat and dehydration for hours after the MDMA ends. Avoid this combination.
- Methamphetamine and MethadoneMeth hides how much the opioid is slowing you, and when it fades, everything you redosed hits at once, often as you fall asleep. Avoid this…
- Methamphetamine and NBOMesTogether they overwork the heart and raise the risk of a seizure, and the trip is more loop-prone. Avoid this combination.
- Methamphetamine and OpioidsMeth hides how much the opioid is slowing you, and when it fades, everything you redosed hits at once, often as you fall asleep. Avoid this…
- Methamphetamine and PCPThis combination easily tips into mania. Avoid it.
- Methamphetamine and PregabalinThis carries a real seizure risk, and if the amphetamine wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
Caution
15- Methamphetamine and 2C-xStimulants make a trip more anxious and loop-prone, and the stimulation together can be uncomfortable. Take less of each than usual, and do not use…
- Methamphetamine and AlcoholMeth hides how drunk you are, so people drink much more across a very long session. Set a drink limit before you start.
- Methamphetamine and AmphetaminesNearly the same drug, but meth lasts far longer, so adding amphetamine stretches the strain on your heart for hours. Treat it as a redose, not a new…
- Methamphetamine and CaffeineTwo stimulants strain the heart and can make you anxious and uncomfortable. Skip the caffeine, or keep it light.
- Methamphetamine and CannabisThe stimulant can make cannabis more anxious and loop-prone. Take less of each than usual.
- Methamphetamine and DiphenhydramineAmphetamines can hide how confused diphenhydramine is making you, and together they strain the heart. Keep diphenhydramine to ordinary medical doses.
- Methamphetamine and DMTThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Methamphetamine and GHB / GBLThe stimulant hides how sedated you are; if it wears off first, the GHB can stop your breathing. Take less of each than usual, and do not use alone.
- Methamphetamine and KetamineLikely to raise blood pressure, and moving around on high doses of both risks injury. Keep doses sensible, and avoid moving around much on high doses.
- Methamphetamine and LSDThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Methamphetamine and MephedroneTwo stimulants strain the heart and brain, usually over a long session of redosing. Decide the total for the night in advance.
- Methamphetamine and MescalinePsychedelics magnify a stimulant's focus and anxiety, making thought loops more likely. Take less of each than usual, and do not use alone.
- Methamphetamine and MushroomsThe stimulant can make a trip more anxious and loop-prone. Take less of each than usual, and do not use alone.
- Methamphetamine and MXETogether they can race the heart, spike blood pressure, and tip into mania. Take less of each than usual, and do not use alone.
- Methamphetamine and SSRIsSSRIs blunt meth, which tempts redosing, while adding serotonin syndrome risk, and some make meth last longer. Do not redose to chase the effect.
Low / synergy
1Low / decrease
1Low / no synergy
5Checking more than one?
This page rates Methamphetamine against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Methamphetamine in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.