Mixing Methamphetamine (meth) and SSRIs (antidepressants)
Caution
SSRIs blunt meth, which tempts redosing, while adding serotonin syndrome risk, and some make meth last longer. Do not redose to chase the effect.
SSRIs blunt methamphetamine's effect, which invites redosing, while adding serotonin toxicity risk. Some SSRIs also inhibit CYP2D6 and slow its clearance, so the dose you take lasts even longer than usual.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Methamphetamine (meth) and SSRIs (antidepressants)?
MixSafe rates mixing Methamphetamine and SSRIs as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Methamphetamine
- Roughly twice as potent, and lasts three to four times as long
- Methamphetamine also called
- meth, crystal, crystal meth, ice, tina, shard
- SSRIs also called
- ssri, zoloft, sertraline, lexapro, escitalopram, prozac
- The Main Molecular Mechanisms Underlying Methamphetamine-Induced Neurotoxicity and Implications for Pharmacological Treatment. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994595/
- Neurobiology and Clinical Manifestations of Methamphetamine Neurotoxicity. Psychiatric Times. https://www.psychiatrictimes.com/view/neurobiology-and-clinical-manifestations-methamphetamine-neurotoxicity
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Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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All combinations →Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.