Combination

Mixing PCP and SSRIs

DissociativeAntidepressant
PCP also called
phencyclidine, angel dust, angeldust, wet, sherm
SSRIs also called
ssri, zoloft, sertraline, lexapro, escitalopram, prozac
Verdict

Unsafe

Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.

Risk / Physical + headspace

This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.

Can you mix PCP and SSRIs?

Risk of serious physical or psychological harm. Not recommended under any circumstances.

Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.

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Related combinations

PCP withWhat not to mix with PCP →
SSRIs withWhat not to mix with SSRIs →
All combinations →

Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.