Substance
What not to mix with Mephedrone (meow)
Stimulant
Also called4-mmc, 4mmc, meow, m-cat, 4-methylmethcathinone, bath salts
Summary
Mephedrone is checked against 40 other substances — 6 dangerous, 1 unsafe and 25 caution.
Dangerous
6- Mephedrone and DiphenhydramineAt recreational doses this risks serotonin syndrome and heart trouble, and if one wears off first the other can overwhelm you. Do not combine.
- Mephedrone and DXMBoth raise serotonin, so together they risk serotonin syndrome, and they also strain the heart. Do not combine.
- Mephedrone and LithiumSerotonin overload plus lithium's effect on the brain raises the risk of seizures. Do not combine.
- Mephedrone and MAOIsAn MAOI stops the body breaking down what mephedrone releases, risking a blood-pressure crisis and serotonin syndrome. Do not combine, and that…
- Mephedrone and MDMABoth raise serotonin, so together they risk serotonin syndrome, strain the heart, and make MDMA more damaging to the brain. Do not combine.
- Mephedrone and TramadolAt recreational doses this risks serotonin syndrome, seizures and heart trouble, and if one wears off first the other can overwhelm you. Do not…
Unsafe
1Caution
25- Mephedrone and 2C-T-xTogether they overstimulate and cause nausea, and 2C-T-x is unpredictable on its own. Take less of each than usual, and do not use alone.
- Mephedrone and 2C-xTwo stimulating drugs together strain the heart. Take less of each than usual, and do not use alone.
- Mephedrone and 5-MeO-xxTBoth act on serotonin, so together they risk serotonin syndrome and heavy overstimulation. Take less of each than usual, and do not use alone.
- Mephedrone and AlcoholAlcohol makes mephedrone feel stronger and makes you want more of both, with worse judgement about each. Decide the total for the night in advance.
- Mephedrone and AmphetaminesTwo stimulants strain the heart and brain, usually over a long session of redosing. Decide the total for the night in advance.
- Mephedrone and AMTBoth release serotonin, so together they carry a real risk of serotonin syndrome and heart strain. Take less of each than usual, and do not use alone.
- Mephedrone and BuprenorphineThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Mephedrone and CaffeineTwo stimulants strain the heart and can make you anxious and uncomfortable. Skip the caffeine, or keep it light.
- Mephedrone and CocaineStacking stimulants strains the heart far more than it adds to the high. Take less of each than usual, and decide the total for the night in advance.
- Mephedrone and CodeineThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Mephedrone and DOxThe stimulant makes a trip more anxious and loop-prone, and together they can overwork the heart. Take less of each than usual, and do not use alone.
- Mephedrone and FentanylThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Mephedrone and GHB / GBLEach hides the other; whichever wears off first can leave you overdosed on the other. Both strain the heart. Take less of each than usual, and do not…
- Mephedrone and KetamineThe stimulant hides how dissociated you are, so people take more ketamine than they meant to. Decide your ketamine dose in advance and do not redose.
- Mephedrone and KratomThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Mephedrone and LSDThe stimulant makes a trip more anxious and loop-prone, and together they can overwork the heart. Take less of each than usual, and do not use alone.
- Mephedrone and MescalineTogether they add stimulation, heart strain and, often, anxiety. Take less of each than usual, and do not use alone.
- Mephedrone and MethadoneThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Mephedrone and MethamphetamineTwo stimulants strain the heart and brain, usually over a long session of redosing. Decide the total for the night in advance.
- Mephedrone and MXEThe stimulant hides how dissociated you are, which tempts redosing, and both strain the heart. Take less of each than usual, and do not use alone.
- Mephedrone and NBOMesNBOMes already strain the heart, and a stimulant adds to that and to the risk of a seizure. Take less of each than usual, and do not use alone.
- Mephedrone and NicotineTogether they strain the heart more, and you will smoke far more over the session. Take less of each than usual.
- Mephedrone and OpioidsThe stimulant hides how much the opioid is slowing you; if it wears off first, breathing can stop. Take less of each than usual, do not use alone…
- Mephedrone and PCPUnpredictable, with more heart strain and worse judgement. Take less of each than usual, and do not use alone.
- Mephedrone and SSRIsSSRIs blunt mephedrone, which tempts redosing, and redosing is what raises the serotonin syndrome risk. Do not redose to chase the effect.
Low / synergy
4Low / decrease
1Low / no synergy
3Checking more than one?
This page rates Mephedrone against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Mephedrone in the checkerOther stimulants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.