Mixing MAOIs and Mephedrone (meow)
Dangerous
An MAOI stops the body breaking down what mephedrone releases, risking a blood-pressure crisis and serotonin syndrome. Do not combine, and that includes ayahuasca and Syrian rue.
Mephedrone releases serotonin, dopamine and noradrenaline. With an MAOI blocking their breakdown, this risks hypertensive crisis and serotonin syndrome. This includes ayahuasca and syrian rue, not only prescription MAOIs. Do not combine.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskWhat to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
Can you mix MAOIs and Mephedrone (meow)?
MixSafe rates mixing MAOIs and Mephedrone as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.
- MAOIs also called
- maoi, nardil, phenelzine, parnate, tranylcypromine, marplan
- Mephedrone also called
- 4-mmc, 4mmc, meow, m-cat, 4-methylmethcathinone, bath salts
- Mephedrone. PsychonautWiki. https://psychonautwiki.org/wiki/Mephedrone
- Mephedrone and Alcohol Interactions in Humans. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999687/
- Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115874/
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Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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All combinations →Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.