Mixing Mephedrone (meow) and Pregabalin (Lyrica)
Unsafe
This carries a real seizure risk, and if the mephedrone wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
There is a significant risk of seizures from this combination. Mephedrone increases respiration rate allowing for a higher dose of sedatives than normal. If mephedrone wears off first, recreational dosages of pregabalin may overcome the individual and cause respiratory arrest. Both substances at recreational dosages cause strain of the heart and may lead to further dangerous heart complications.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskWhat to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
Can you mix Mephedrone (meow) and Pregabalin (Lyrica)?
MixSafe rates mixing Mephedrone and Pregabalin as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Mephedrone also called
- 4-mmc, 4mmc, meow, m-cat, 4-methylmethcathinone, bath salts
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Rated unsafe. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.