Mixing Pregabalin (Lyrica) and Xylazine (tranq)

Q: How dangerous is Pregabalin with Xylazine?

Dangerous: High risk of death or life-changing injury. Do not combine.

Q: Is it safe to mix Lyrica and tranq?

MixSafe lists Lyrica under Pregabalin and tranq under Xylazine. That combination is rated "Dangerous". Gabapentinoids carry an FDA warning for slowed breathing when combined with other sedatives, and xylazine is a strong one. Pregabalin's sedation peaks late, and naloxone reverses neither.

Dangerous

Pregabalin adds late-peaking sedation and slowed breathing to xylazine's, and naloxone reverses neither.

Do this

Do not combine.

Where the risk isTap for why

In an emergency, call 911911 Never Use Alone Poison Control

What to do

Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.

What “Dangerous” means

High risk of death or life-changing injury. Do not combine.

How the ratings work

The longer explanation

Gabapentinoids carry an FDA warning for slowed breathing when combined with other sedatives, and xylazine is a strong one. Pregabalin's sedation peaks late, and naloxone reverses neither.

Sources (6)

What You Should Know About Xylazine. CDCcdc.gov
Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
FDA Warns of Respiratory Depression With Gabapentinoidsneurologylive.com
Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Healthpharmacyservices.utah.edu
Deaths related to the combination of pregabalin and other drugs of abusesciencedirect.com

Think this is wrong, or know a better source? Send it.

Other names

Pregabalin: lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
Xylazine: tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine; Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither

Add a third substance in the checker

Related combinations

Pregabalin with

What not to mix with Pregabalin →

Xylazine with

What not to mix with Xylazine →

All combinations →

Can you mix Pregabalin (Lyrica) and Xylazine (tranq)?

MixSafe rates mixing Pregabalin and Xylazine as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.