Substance
What not to mix with Pregabalin
Depressant
Also calledlyrica, pregablin, gabapentin, gaba
Summary
Pregabalin is checked against 40 other substances — 9 dangerous, 10 unsafe and 13 caution.
Dangerous
9- Pregabalin and AlcoholGabapentinoids cause respiratory depression in their own right, and the FDA's review found that risk concentrated almost entirely in people also…
- Pregabalin and BenzodiazepinesAdditive respiratory depression between two CNS depressants, and a combination that appears repeatedly in overdose death reports. Both also cause…
- Pregabalin and BuprenorphineHigh risk of death or life-changing injury. Do not combine.
- Pregabalin and CodeineHigh risk of death or life-changing injury. Do not combine.
- Pregabalin and FentanylGabapentinoids carry an FDA respiratory-depression warning specifically for combination with opioids, and pregabalin appears in a rising share of…
- Pregabalin and GHB / GBLThe two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side…
- Pregabalin and MethadoneHigh risk of death or life-changing injury. Do not combine.
- Pregabalin and NBOMesNBOMes and pregabalin are reported to have significant seizure concerns that are likely to increase in combination. Therapeutic dosages of pregabalin…
- Pregabalin and OpioidsHigh risk of death or life-changing injury. Do not combine.
Unsafe
10- Pregabalin and AmphetaminesThere is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than…
- Pregabalin and CaffeineThere is a risk of seizures from this combination, especially at higher dosages. Caffeine additionally reduces pregabalin’s anticonvulsant effects…
- Pregabalin and CocaineThere is a significant risk of seizures from this combination. Stimulants increase respiration rate, allowing for a higher dose of sedatives than…
- Pregabalin and DiphenhydramineThere is a significant risk of seizures from this combination. The combination is likely to increase each other’s negative side effects, such as…
- Pregabalin and DXMPregabalin and DXM may increase each other’s effects such as inhibition, dizziness, sedation. At higher doses this can lead to unexpected loss of…
- Pregabalin and KratomGabapentinoids potentiate opioid respiratory depression and carry an FDA warning for exactly this. The sedation arrives later than you expect and…
- Pregabalin and MDMAThere is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than…
- Pregabalin and MephedroneThere is a significant risk of seizures from this combination. Mephedrone increases respiration rate allowing for a higher dose of sedatives than…
- Pregabalin and MethamphetamineThere is a significant risk of seizures from this combination. Amphetamines increase respiration rate allowing for a higher dose of sedatives than…
- Pregabalin and TramadolThere is a significant risk of seizures. Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances…
Caution
13- Pregabalin and 2C-T-xSedation blunts and muddles the psychedelic effect, which invites redosing the psychedelic. Consistent with how pregabalin is rated against other…
- Pregabalin and 5-MeO-xxTCaution should be given due to 5-MeO-xxT drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
- Pregabalin and AMTMixed stimulant-psychedelic against a sedative — unpredictable, and the sedation masks how much AMT is on board.
- Pregabalin and DOxCaution should be given due to DOx drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
- Pregabalin and KetaminePregabalin and ketamine may synergize and increase each other's negative side effects such as nausea, dizziness, and loss of consciousness. Caution…
- Pregabalin and LithiumAdditive sedation and dizziness. No direct interaction on lithium levels, but both impair coordination.
- Pregabalin and LSDCaution should be given due to LSD’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
- Pregabalin and MAOIsAdditive sedation and blood-pressure effects. Little direct data; treat as unpredictable.
- Pregabalin and MescalineCaution should be given due to mescaline’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
- Pregabalin and MXEPregabalin and MXE may synergize and increase each other’s negative side effects such as nausea, dizziness, and loss of consciousness. Caution is…
- Pregabalin and Nitrous OxideBoth substances potentiate the ataxia and sedation caused by the other, and may increase the risk of loss of consciousness at higher dosages. While…
- Pregabalin and PCPAdditive sedation, disinhibition and impaired coordination, with a substantially raised risk of blackout.
- Pregabalin and SSRIsAdditive sedation and dizziness. No serotonergic interaction, but the combined impairment is more than people expect from a prescribed pair.
Low / synergy
5Low / no synergy
3Checking more than one?
This page rates Pregabalin against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Pregabalin in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.