Substance
What not to mix with Pregabalin (Lyrica)
Depressant
Also calledlyrica, pregablin, gabapentin, gaba, neurontin, gabbies
Summary
Pregabalin is checked against 40 other substances — 9 dangerous, 10 unsafe and 13 caution.
Dangerous
9- Pregabalin and AlcoholTogether they can stop your breathing, and pregabalin's slow start tempts people to take more before it peaks. Do not combine. Do not redose, and put…
- Pregabalin and BenzodiazepinesTogether they can stop your breathing, and both cause blackouts, so people redose without remembering the first dose. Do not combine.
- Pregabalin and BuprenorphineHigh risk of death or life-changing injury. Do not combine.
- Pregabalin and CodeineHigh risk of death or life-changing injury. Do not combine.
- Pregabalin and FentanylPregabalin carries an FDA warning for slowed breathing with opioids, and its sedation peaks late. Do not combine. Keep naloxone nearby.
- Pregabalin and GHB / GBLEach makes the other much stronger: blackouts, unconsciousness and seizures all become more likely. Do not combine. If someone passes out, put them…
- Pregabalin and MethadoneHigh risk of death or life-changing injury. Do not combine.
- Pregabalin and NBOMesBoth carry a seizure risk, and together it is likely to go up. Do not combine at recreational doses of pregabalin.
- Pregabalin and OpioidsHigh risk of death or life-changing injury. Do not combine.
Unsafe
10- Pregabalin and AmphetaminesThis carries a real seizure risk, and if the amphetamine wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
- Pregabalin and CaffeineTogether they raise the risk of seizures, and if the caffeine wears off first, pregabalin can slow breathing. Avoid this combination at recreational…
- Pregabalin and CocaineThis carries a real seizure risk, and if the cocaine wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
- Pregabalin and DiphenhydramineThis carries a real seizure risk and makes passing out more likely. Avoid this combination at recreational doses.
- Pregabalin and DXMEach makes the other stronger, and together they can knock you out and raise the risk of a seizure. Avoid this combination.
- Pregabalin and KratomPregabalin makes opioid-type drugs slow breathing more, and its sedation comes late and lasts. Avoid this combination.
- Pregabalin and MDMAThis carries a real seizure risk, and if the MDMA wears off first, pregabalin can slow breathing dangerously. Avoid this combination at recreational…
- Pregabalin and MephedroneThis carries a real seizure risk, and if the mephedrone wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
- Pregabalin and MethamphetamineThis carries a real seizure risk, and if the amphetamine wears off first, pregabalin can slow breathing dangerously. Avoid this combination.
- Pregabalin and TramadolTogether they raise the seizure risk and can knock you out. Avoid this combination at recreational doses. If someone passes out, put them on their…
Caution
13- Pregabalin and 2C-T-xPregabalin muddies the trip, which tempts people to take more of the psychedelic. Do not redose, and do not use alone.
- Pregabalin and 5-MeO-xxT5-MeO drugs are stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of…
- Pregabalin and AMTThe sedation hides how much AMT you have taken, and the mix is unpredictable. Take less of each than usual, and do not use alone.
- Pregabalin and DOxDOx is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of each than…
- Pregabalin and KetamineEach can make the other's nausea, dizziness and blackouts worse, and higher doses raise the risk of a seizure. Take less of each than usual, and do…
- Pregabalin and LithiumTogether they add drowsiness and dizziness. Take care with anything that needs coordination.
- Pregabalin and LSDLSD is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of each than…
- Pregabalin and MAOIsTogether they add sedation and affect blood pressure, and there is little data. Take less of each than usual, and do not use alone.
- Pregabalin and MescalineMescaline is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of…
- Pregabalin and MXEEach can make the other's nausea, dizziness and blackouts worse, and more than low doses raise the risk of a seizure. Take less of each than usual…
- Pregabalin and Nitrous OxideEach makes the other stronger, so passing out and injury are more likely, and heavy nitrous use raises the risk of a seizure. Take less of each than…
- Pregabalin and PCPTogether they add sedation and clumsiness, and blackouts become much more likely. Take less of each than usual, and do not use alone.
- Pregabalin and SSRIsTogether they cause more drowsiness and dizziness than people expect from two prescriptions. Expect to be more impaired than on either alone.
Low / synergy
5Low / no synergy
3Checking more than one?
This page rates Pregabalin against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Pregabalin in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.