Mixing DOx and Pregabalin (Lyrica)
Caution
DOx is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of each than usual, and do not use alone.
Caution should be given due to DOx drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the vasoconstriction, anxiety, and other side effects of DOx drugs. Additionally, Pregabalin may increase DOx drugs inhibition and risk of injury.
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix DOx and Pregabalin (Lyrica)?
MixSafe rates mixing DOx and Pregabalin as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- DOx also called
- dom, doc, doi, dob, don
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
Think this rating or note is wrong, or know a better source? Send it.
Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.