Substance
What not to mix with DOx
PsychedelicDrug class
Also calleddom, doc, doi, dob, don
Summary
DOx is checked against 40 other substances — 2 dangerous, 6 unsafe and 13 caution.
Dangerous
2Unsafe
6- DOx and AmphetaminesTogether they are heavy on the body and prone to thought loops, and coming down from the amphetamine while the DOx is still going is very anxious…
- DOx and CocaineTogether they are heavy on the body and prone to thought loops, and coming down from the cocaine while the DOx is still going is very anxious. Avoid…
- DOx and DXMDOx can hide how much DXM you have taken, which leads to redosing, and DXM can make the DOx very intense. Avoid this combination.
- DOx and MethamphetamineTogether they are heavy on the body and prone to thought loops, and coming down from the amphetamine while the DOx is still going is very anxious…
- DOx and PCPLittle is known about this pair, and PCP interacts unpredictably. Avoid this combination.
- DOx and TramadolTramadol lowers the seizure threshold and psychedelics can cause seizures, so together a seizure becomes more likely. Avoid this combination.
Caution
13- DOx and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and 5-MeO-xxT5-MeO drugs interact unpredictably, especially with more uncomfortable body effects. Take less of each than usual, and do not use alone.
- DOx and CaffeineCaffeine's anxiety is harder to manage while tripping, and together they can be physically uncomfortable. Keep caffeine light.
- DOx and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- DOx and DiphenhydramineBeyond an ordinary 25–50 mg dose of diphenhydramine, DOx makes its delirium worse and adds heart strain. Keep diphenhydramine to that dose.
- DOx and MAOIsMAOIs can make DOx much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- DOx and MDMAThe stimulation together can be uncomfortable, and coming down from MDMA while DOx is still going is very anxious. Take less of each than usual, and…
- DOx and MephedroneThe stimulant makes a trip more anxious and loop-prone, and together they can overwork the heart. Take less of each than usual, and do not use alone.
- DOx and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and MXEMXE makes DOx stronger, which can be unpleasantly intense. Take less of each than usual, and do not use alone.
- DOx and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and PregabalinDOx is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of each than…
Low / synergy
5Low / decrease
4Low / no synergy
10Checking more than one?
This page rates DOx against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open DOx in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.