Substance
What not to mix with DOx
PsychedelicDrug class
Also calleddom, doc, doi, dob, don
Summary
DOx is checked against 40 other substances — 2 dangerous, 6 unsafe and 13 caution.
Dangerous
2Unsafe
6- DOx and AmphetaminesThe combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to…
- DOx and CocaineThe combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought…
- DOx and DXMThe DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also…
- DOx and MethamphetamineThe combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to…
- DOx and PCPDetails of this combination are not well understood but PCP generally interacts in an unpredictable manner.
- DOx and TramadolTramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
Caution
13- DOx and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and 5-MeO-xxTThe 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
- DOx and CaffeineHigh doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
- DOx and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- DOx and DiphenhydramineAt 25-50mg, DPH may assist with side effects of DOx drugs such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and DOx…
- DOx and MAOIsMAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably
- DOx and MDMAThe combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
- DOx and MephedroneThe anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops, in addition to the possible negative side effects…
- DOx and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and MXEAs an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
- DOx and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- DOx and PregabalinCaution should be given due to DOx drugs stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
Low / synergy
5Low / decrease
4Low / no synergy
10Checking more than one?
This page rates DOx against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open DOx in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.