Substance
What not to mix with Mescaline (peyote)
Psychedelic
Also calledpeyote, san pedro, san-pedro, mesc, buttons
Summary
Mescaline is checked against 40 other substances — 2 dangerous, 1 unsafe and 13 caution.
Dangerous
2Unsafe
1Caution
13- Mescaline and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and 5-MeO-xxT5-MeO drugs interact unpredictably. Take less of each than usual, and do not use alone.
- Mescaline and AmphetaminesPsychedelics magnify a stimulant's focus and anxiety, making thought loops more likely. Take less of each than usual, and do not use alone.
- Mescaline and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Mescaline and CocainePsychedelics magnify a stimulant's focus and anxiety, making thought loops more likely. Take less of each than usual, and do not use alone.
- Mescaline and DiphenhydramineBeyond an ordinary 25–50 mg dose of diphenhydramine, mescaline makes its delirium worse and injury more likely. Keep diphenhydramine to that dose.
- Mescaline and DOxCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and MAOIsCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and MephedroneTogether they add stimulation, heart strain and, often, anxiety. Take less of each than usual, and do not use alone.
- Mescaline and MethamphetaminePsychedelics magnify a stimulant's focus and anxiety, making thought loops more likely. Take less of each than usual, and do not use alone.
- Mescaline and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and PregabalinMescaline is stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of…
Low / synergy
9Low / decrease
4Low / no synergy
11Checking more than one?
This page rates Mescaline against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Mescaline in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.