Substance
What not to mix with Mescaline
Psychedelic
Also calledpeyote, san pedro, san-pedro, mesc, buttons
Summary
Mescaline is checked against 40 other substances — 2 dangerous, 1 unsafe and 13 caution.
Dangerous
2Unsafe
1Caution
13- Mescaline and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and 5-MeO-xxTThe 5-MeO class of tryptamines can be unpredictable in their interactions
- Mescaline and AmphetaminesThe focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Mescaline and CannabisCannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
- Mescaline and CocaineThe focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Mescaline and DiphenhydramineAt 25-50mg, DPH may assist with side effects of the mescaline such as nausea and anxiety. At higher dosages, the combination of a deliriant (DPH) and…
- Mescaline and DOxCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and MAOIsCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and MephedroneAdditive stimulation and cardiovascular strain, with amplified anxiety a common outcome.
- Mescaline and MethamphetamineThe focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
- Mescaline and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- Mescaline and PregabalinCaution should be given due to mescaline’s stimulating effects and pregabalin’s seizure concerns at higher dosages. Pregabalin may reduce the…
Low / synergy
9Low / decrease
4Low / no synergy
11Checking more than one?
This page rates Mescaline against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Mescaline in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.