Substance
What not to mix with NBOMes
PsychedelicDrug class
Also called25i, 25i-nbome, 25c-nbome, 25b-nbome, n-bomb, nbome
Summary
NBOMes is checked against 40 other substances — 3 dangerous, 5 unsafe and 12 caution.
Dangerous
3- NBOMes and AMTHigh risk of death or life-changing injury. Do not combine.
- NBOMes and LithiumMany reports link this combination to seizures and psychosis. Do not combine.
- NBOMes and PregabalinBoth carry a seizure risk, and together it is likely to go up. Do not combine at recreational doses of pregabalin.
Unsafe
5- NBOMes and AmphetaminesTogether they overwork the heart and raise the risk of a seizure, and the trip is more loop-prone. Avoid this combination.
- NBOMes and CocaineBoth are strongly stimulating: together they can race the heart, spike blood pressure, and in extreme cases cause heart failure. Avoid this…
- NBOMes and DXMRisk of serious physical or psychological harm. Not recommended under any circumstances.
- NBOMes and MethamphetamineTogether they overwork the heart and raise the risk of a seizure, and the trip is more loop-prone. Avoid this combination.
- NBOMes and TramadolTramadol lowers the seizure threshold and NBOMes can cause severe seizures. Avoid this combination.
Caution
12- NBOMes and 2C-T-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and 5-MeO-xxTBoth are unpredictable, NBOMes even on their own. This one is best avoided.
- NBOMes and CaffeineCaffeine brings out the stimulation in a psychedelic and makes the anxiety harder to handle. Keep caffeine light.
- NBOMes and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- NBOMes and DiphenhydramineBeyond an ordinary 25–50 mg dose of diphenhydramine, NBOMes make its delirium worse and add heart strain. Keep diphenhydramine to that dose.
- NBOMes and DOxCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and MAOIsMAOIs can make NBOMes much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- NBOMes and MDMACarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and MephedroneNBOMes already strain the heart, and a stimulant adds to that and to the risk of a seizure. Take less of each than usual, and do not use alone.
- NBOMes and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- NBOMes and MXEMXE makes NBOMes stronger, which can be unpleasantly intense. Take less of each than usual, and do not use alone.
Low / synergy
6Low / decrease
4Low / no synergy
10Checking more than one?
This page rates NBOMes against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open NBOMes in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.