Substance
What not to mix with 2C-T-x
PsychedelicDrug class
Also called2c-t-2, 2c-t-7, 2c-t-21
Summary
2C-T-x is checked against 40 other substances — 3 dangerous, 5 unsafe and 12 caution.
Dangerous
3Unsafe
5- 2C-T-x and AmphetaminesStimulants make a trip more anxious and loop-prone, and together they can overwork the heart. Avoid this combination.
- 2C-T-x and CocaineBoth are strongly stimulating: together they can race the heart, spike blood pressure, and in extreme cases cause heart failure. Avoid this…
- 2C-T-x and DXMRisk of serious physical or psychological harm. Not recommended under any circumstances.
- 2C-T-x and MethamphetamineStimulants make a trip more anxious and loop-prone, and together they can overwork the heart. Avoid this combination.
- 2C-T-x and TramadolRisk of serious physical or psychological harm. Not recommended under any circumstances.
Caution
12- 2C-T-x and 2C-xCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and 5-MeO-xxTBoth can be unpredictable on their own. Take less of each than usual, and do not use alone.
- 2C-T-x and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- 2C-T-x and DiphenhydramineTogether they add confusion and discomfort, and diphenhydramine makes 2C-T-x's nausea worse. Take less of each than usual, and do not use alone.
- 2C-T-x and DOxCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and MAOIsMAOIs can make 2C-T-x much stronger and longer-lasting in ways that are hard to predict. Take less of each than usual, and do not use alone.
- 2C-T-x and MDMACarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and MephedroneTogether they overstimulate and cause nausea, and 2C-T-x is unpredictable on its own. Take less of each than usual, and do not use alone.
- 2C-T-x and MescalineCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and MXECarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and NBOMesCarries risk that is worth understanding before combining. Reduce doses and do not use alone.
- 2C-T-x and PregabalinPregabalin muddies the trip, which tempts people to take more of the psychedelic. Do not redose, and do not use alone.
Low / synergy
5Low / decrease
4Low / no synergy
11Checking more than one?
This page rates 2C-T-x against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open 2C-T-x in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.