Substance
What not to mix with 5-MeO-xxT (5-MeO-DMT)
PsychedelicDrug class
Also called5-meo-dmt, 5-meo-mipt, 5-meo-dipt, foxy, toad, bufo
Summary
5-MeO-xxT is checked against 40 other substances — 4 dangerous, 5 unsafe and 10 caution.
Dangerous
4- 5-MeO-xxT and AMTHigh risk of death or life-changing injury. Do not combine.
- 5-MeO-xxT and LithiumLithium with psychedelics is linked to seizures: in one analysis of user reports, nearly half involved one. Do not combine.
- 5-MeO-xxT and MAOIsHigh risk of death or life-changing injury. Do not combine.
- 5-MeO-xxT and PCPHigh risk of death or life-changing injury. Do not combine.
Unsafe
5- 5-MeO-xxT and AmphetaminesStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating. Avoid this combination.
- 5-MeO-xxT and CocaineStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating. Avoid this combination.
- 5-MeO-xxT and DXMLittle is known about this combination. Avoid it.
- 5-MeO-xxT and MethamphetamineStimulants make a trip more anxious and loop-prone, and a psychedelic is already stimulating. Avoid this combination.
- 5-MeO-xxT and TramadolRisk of serious physical or psychological harm. Not recommended under any circumstances.
Caution
10- 5-MeO-xxT and 2C-T-xBoth can be unpredictable on their own. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and 2C-x5-MeO drugs can make other psychedelics unpredictably stronger. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and CannabisCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and DiphenhydramineDelirium on top of a short, intense trip is disorienting and hard to manage. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and DOx5-MeO drugs interact unpredictably, especially with more uncomfortable body effects. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and MDMASome 5-MeO drugs are unpredictable with MDMA. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and MephedroneBoth act on serotonin, so together they risk serotonin syndrome and heavy overstimulation. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and Mescaline5-MeO drugs interact unpredictably. Take less of each than usual, and do not use alone.
- 5-MeO-xxT and NBOMesBoth are unpredictable, NBOMes even on their own. This one is best avoided.
- 5-MeO-xxT and Pregabalin5-MeO drugs are stimulating and high doses of pregabalin carry a seizure risk; pregabalin can also make falls and injuries more likely. Take less of…
Low / synergy
6Low / decrease
4Low / no synergy
11Checking more than one?
This page rates 5-MeO-xxT against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open 5-MeO-xxT in the checkerOther psychedelics
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.