Mixing 5-MeO-xxT (5-MeO-DMT) and Lithium
Dangerous
Lithium with psychedelics is linked to seizures: in one analysis of user reports, nearly half involved one. Do not combine.
Lithium taken alongside classic 5-HT2A psychedelics is associated with seizures — in an analysis of user reports, 47% of lithium-plus-psychedelic cases involved a seizure and 39% required medical attention. Lithium is one of the clearest red-flag medications in psychedelic harm reduction. Do not combine.
This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.
Headspace vs physical riskWhat to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
Can you mix 5-MeO-xxT (5-MeO-DMT) and Lithium?
MixSafe rates mixing 5-MeO-xxT and Lithium as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.
- 5-MeO-xxT also called
- 5-meo-dmt, 5-meo-mipt, 5-meo-dipt, foxy, toad, bufo
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- Nayak SM et al. Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures. Johns Hopkins, 2021. https://pure.johnshopkins.edu/en/publications/classic-psychedelic-coadministration-with-lithium-but-not-lamotri/
- Mixing psychedelics with lithium poses significant risk of seizures. https://psychedelichealth.co.uk/2021/08/13/mixing-psychedelics-with-lithium-poses-significant-risk-of-seizures/
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All combinations →Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.