Substance
What not to mix with Lithium
Other
Also calledlithium carbonate, lithobid, mood stabilizer
Summary
Lithium is checked against 40 other substances — 15 dangerous, 1 unsafe and 13 caution.
Dangerous
15- Lithium and 2C-T-xMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and 2C-xMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and 5-MeO-xxTLithium with psychedelics is linked to seizures: in one analysis of user reports, nearly half involved one. Do not combine.
- Lithium and AMTLithium with psychedelics carries a well-documented seizure risk. Do not combine.
- Lithium and DMTMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and DOxMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and DXMTogether they risk serotonin syndrome. Do not combine.
- Lithium and LSDMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and MDMATogether they carry a high risk of serotonin syndrome. Do not combine.
- Lithium and MephedroneSerotonin overload plus lithium's effect on the brain raises the risk of seizures. Do not combine.
- Lithium and MescalineMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and MushroomsMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and MXELithium can set off serotonin syndrome with serotonin-acting drugs, and MXE is one. Do not combine.
- Lithium and NBOMesMany reports link this combination to seizures and psychosis. Do not combine.
- Lithium and TramadolBoth raise the risk of seizures and of serotonin syndrome. Do not combine.
Unsafe
1Caution
13- Lithium and AlcoholDehydration from drinking can push lithium toward toxic levels, worse with vomiting or sweating. Drink less, and keep up water.
- Lithium and BuprenorphineTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Lithium and CaffeineHeavy caffeine lowers lithium levels, and stopping suddenly can push them back up toward toxic. Keep your caffeine intake steady.
- Lithium and CodeineTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Lithium and DiphenhydramineHigher doses of diphenhydramine risk serotonin syndrome and heart-rhythm problems with lithium. Keep diphenhydramine to an ordinary 25–50 mg.
- Lithium and FentanylTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Lithium and GHB / GBLTogether they add sedation, and dehydration can raise lithium levels; GHB's narrow dose range is the main danger. Take less GHB than usual, and do…
- Lithium and KratomTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Lithium and MAOIsBoth raise serotonin, so together they risk serotonin syndrome. Do not add this recreationally.
- Lithium and MethadoneTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Lithium and OpioidsTogether they add sedation, and dehydration can push lithium levels up. Keep up water, and keep naloxone nearby.
- Lithium and PCPLithium lowers the seizure threshold, and how dissociatives interact with it is poorly reported. Take less PCP than usual, and do not use alone.
- Lithium and PregabalinTogether they add drowsiness and dizziness. Take care with anything that needs coordination.
Low / decrease
1Low / no synergy
10Checking more than one?
This page rates Lithium against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Lithium in the checkerEducational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.