Mixing Lithium and Pregabalin (Lyrica)
Caution
Together they add drowsiness and dizziness. Take care with anything that needs coordination.
Additive sedation and dizziness. No direct interaction on lithium levels, but both impair coordination.
The risk here is to the body — breathing, heart, temperature or organs. Set limits before you start, because this kind of harm does not announce itself in time to react.
Headspace vs physical riskCan you mix Lithium and Pregabalin (Lyrica)?
MixSafe rates mixing Lithium and Pregabalin as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
- FDA Warns of Respiratory Depression With Gabapentinoids. https://www.neurologylive.com/view/fda-warns-about-respiratory-depression-with-gabapentinoids
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Health. https://pharmacyservices.utah.edu/alerts/2019/12/gabapentin-and-pregabalin-may-increase-risk-of-respiratory-depression
- Deaths related to the combination of pregabalin and other drugs of abuse. https://www.sciencedirect.com/science/article/abs/pii/S2352007822003316
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.