Mixing Pregabalin (Lyrica) and Zolpidem (Ambien)
Dangerous
Together they can stop your breathing, and both cause blackouts, so people redose without remembering the first dose.
Do not combine.
General answer for Benzodiazepines: nothing specific to these two is documented.
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means
High risk of death or life-changing injury. Do not combine.
How the ratings workThe longer explanation
Additive respiratory depression between two CNS depressants, and a combination that appears repeatedly in overdose death reports. Both also cause blackouts, so the usual failure mode is redosing with no memory of the earlier dose.
Sources (3)
- FDA Warns of Respiratory Depression With Gabapentinoidsneurologylive.com
- Gabapentin and Pregabalin May Increase Risk of Respiratory Depression. University of Utah Healthpharmacyservices.utah.edu
- Deaths related to the combination of pregabalin and other drugs of abusesciencedirect.com
Think this is wrong, or know a better source? Send it.
Other names
- Pregabalin
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
- Zolpidem
- ambien, ambien cr, stilnox, edluar, intermezzo, zolpimist
- Works like a benzo, plus sleepwalking and sleep-driving with no memory of it
Related combinations
- NBOMesDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- XylazineDangerous
- GHB / GBLDangerous
- OpioidsDangerous
Can you mix Pregabalin (Lyrica) and Zolpidem (Ambien)?
MixSafe rates mixing Pregabalin and Zolpidem as "Dangerous" — high risk of death or life-changing injury. Do not combine. No interaction specific to Pregabalin and Zolpidem is documented; this is the default for Benzodiazepines. Source: MixSafe research. Educational information, not medical advice.
This is a class-level answer, inherited from Benzodiazepines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.