Mixing Opioids and Zolpidem (Ambien)

Dangerous

Together they can slow or stop breathing and knock you out very quickly.

Do this

Do not combine. Keep naloxone nearby, and put anyone who passes out on their side.

General answer for Benzodiazepines: nothing specific to these two is documented.

Where the risk isTap for why
In an emergency, call 911911Never Use AlonePoison Control
What to do
  • Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
  • Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
  • Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
  • Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
  • Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
  • Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means

High risk of death or life-changing injury. Do not combine.

How the ratings work
The longer explanation

Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely

Sources (1)

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Other names
Opioids
opiate, opiates, opioid, heroin, dope, smack
Full agonists — heroin, oxycodone, morphine
Zolpidem
ambien, ambien cr, stilnox, edluar, intermezzo, zolpimist
Works like a benzo, plus sleepwalking and sleep-driving with no memory of it
Also searched asopioids and Ambien, opioids and ambien cr
Add a third substance in the checker

Related combinations

Opioids withWhat not to mix with Opioids →
Zolpidem withWhat not to mix with Zolpidem →
All combinations →

Can you mix Opioids and Zolpidem (Ambien)?

MixSafe rates mixing Opioids and Zolpidem as "Dangerous" — high risk of death or life-changing injury. Do not combine. No interaction specific to Opioids and Zolpidem is documented; this is the default for Benzodiazepines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Benzodiazepines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.