Combination

Mixing Ketamine and Opioids

DissociativeOpioid
Ketamine also called
ket, special k, kitty, kittens
Opioids also called
opiate, opiates, opioid, heroin, dope, smack
Verdict

Dangerous

Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.

Risk / Physical + headspace

This combination carries bodily risk and can go badly psychologically. The headspace part often arrives first and makes the physical part harder to notice.

Can you mix Ketamine and Opioids?

High risk of death or life-changing injury. Do not combine.

Opioids
Full agonists — heroin, oxycodone, morphine
Source

TripSit drug combination chart, retrieved 2026-08-20. View the dataset.

Checking more than two?

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Rated dangerous. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.