Mixing Xylazine (tranq) and Zolpidem (Ambien)
Dangerous
Zolpidem adds benzo-like sedation to xylazine's, and naloxone reverses neither.
Do this
Do not combine. Put anyone who won't wake on their side.
Where the risk isTap for why
What to do
- Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
- Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
- Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
- Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
- Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means
High risk of death or life-changing injury. Do not combine.
How the ratings workThe longer explanation
Zolpidem works on the same receptor as benzodiazepines and adds sedation and slowed breathing to xylazine's, with neither reversed by naloxone. Taking a sleeping pill to come down makes an overdose look like going to sleep.
Sources (6)
- What You Should Know About Xylazine. CDCcdc.gov
- Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
- Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
- FDA adds Boxed Warning for risk of serious injuries caused by sleepwalking with certain prescription insomnia medicines. 2019fda.gov
- Ambien (zolpidem) prescribing information. FDA, 2022accessdata.fda.gov
- Emergency Department Visits for Adverse Reactions Involving the Insomnia Medication Zolpidem. SAMHSA DAWN Report. 2013ncbi.nlm.nih.gov
Think this is wrong, or know a better source? Send it.
Other names
- Xylazine
- tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine
- Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither
- Zolpidem
- ambien, ambien cr, stilnox, edluar, intermezzo, zolpimist
- Works like a benzo, plus sleepwalking and sleep-driving with no memory of it
Also searched astranq and Ambien, tranq dope and Ambien, tranq and ambien cr, tranq dope and ambien cr
Related combinations
Xylazine with
- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- GHB / GBLDangerous
- PregabalinDangerous
Zolpidem with
All combinations →- AlcoholDangerous
- GHB / GBLDangerous
- PregabalinDangerous
- OpioidsDangerous
- FentanylDangerous
- KratomDangerous
Can you mix Xylazine (tranq) and Zolpidem (Ambien)?
MixSafe rates mixing Xylazine and Zolpidem as "Dangerous" — high risk of death or life-changing injury. Do not combine. Source: MixSafe research. Educational information, not medical advice.