Mixing Cannabis (weed) and Lithium
Low risk, no synergy
No documented pharmacological interaction. Cannabis is not a classic 5-HT2A psychedelic, so it does not carry the seizure association that LSD or psilocybin do with lithium.
Can you mix Cannabis (weed) and Lithium?
MixSafe rates mixing Cannabis and Lithium as "Low risk, no synergy" — neither substance is expected to meaningfully change the other. Both still carry their own individual risks. Source: MixSafe research. Educational information, not medical advice.
- Cannabis also called
- weed, pot, marijuana, thc, hash, edibles
- Lithium also called
- lithium carbonate, lithobid, mood stabilizer
- Nayak SM et al., Johns Hopkins, 2021. https://pure.johnshopkins.edu/en/publications/classic-psychedelic-coadministration-with-lithium-but-not-lamotri/
- Ibuprofen interactions to avoid (renal lithium clearance). https://www.singlecare.com/blog/ibuprofen-interactions/
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
All combinations →Rated low / no synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.