Substance
What not to mix with Cannabis (weed)
Depressant
Also calledweed, pot, marijuana, thc, hash, edibles
Summary
Cannabis is checked against 40 other substances — 14 caution.
Caution
14- Cannabis and 2C-T-xCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and 2C-xCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and 5-MeO-xxTCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and AmphetaminesThe stimulant can make cannabis more anxious and loop-prone. Take less of each than usual.
- Cannabis and AMTCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and CocaineThe stimulant can make cannabis more anxious and loop-prone. Take less of each than usual.
- Cannabis and DiphenhydramineTogether they usually cause more confusion and anxiety than either alone. Take less of each than usual.
- Cannabis and DMTCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and DOxCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and LSDCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and MescalineCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and MethamphetamineThe stimulant can make cannabis more anxious and loop-prone. Take less of each than usual.
- Cannabis and MushroomsCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
- Cannabis and NBOMesCannabis can make a trip much stronger and less predictable than you expect. Take less of each than usual, and do not use alone.
Low / synergy
20Low / decrease
1Low / no synergy
5Checking more than one?
This page rates Cannabis against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open Cannabis in the checkerOther depressants
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.