Mixing Cannabis (weed) and Xylazine (tranq)
Caution
Mostly more sedation and dizziness, and xylazine's low blood pressure can make you faint when you stand.
Do this
Take less, get up slowly, and don't use alone.
Where the risk isTap for why
What “Caution” means
Carries risk that is worth understanding before combining. Reduce doses and do not use alone.
How the ratings workThe longer explanation
Mostly additive sedation and dizziness. Xylazine lowers blood pressure and heart rate, so standing up quickly can mean fainting.
Sources (3)
- What You Should Know About Xylazine. CDCcdc.gov
- Ruiz-Colón K et al. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014sciencedirect.com
- Friedman J et al. Xylazine spreads across the US: a growing component of the increasingly synthetic and polysubstance overdose crisis. Drug Alcohol Depend. 2022pubmed.ncbi.nlm.nih.gov
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Other names
- Cannabis
- weed, pot, marijuana, thc, hash, edibles
- Xylazine
- tranq, tranq dope, zombie drug, anestesia de caballo, rompun, medetomidine
- Animal sedative cut into fentanyl, as is its stronger cousin medetomidine — naloxone reverses neither
Also searched asweed and tranq, pot and tranq, weed and tranq dope, pot and tranq dope
Related combinations
Cannabis withWhat not to mix with Cannabis →
Xylazine with
All combinations →- KetamineDangerous
- MXEDangerous
- AlcoholDangerous
- BenzodiazepinesDangerous
- ZolpidemDangerous
- GHB / GBLDangerous
Can you mix Cannabis (weed) and Xylazine (tranq)?
MixSafe rates mixing Cannabis and Xylazine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.