Mixing Cannabis (weed) and Diphenhydramine (Benadryl)
Caution
Together they usually cause more confusion and anxiety than either alone. Take less of each than usual.
Both can produce confusion and, at higher doses, hallucination. Together they commonly produce more disorientation and anxiety than either alone.
The risk here is to the experience — intensity, panic, thought loops, confusion. Physical harm is unlikely at ordinary doses. Setting, company and dose do most of the work.
Headspace vs physical riskCan you mix Cannabis (weed) and Diphenhydramine (Benadryl)?
MixSafe rates mixing Cannabis and Diphenhydramine as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. Source: MixSafe research. Educational information, not medical advice.
- Cannabis also called
- weed, pot, marijuana, thc, hash, edibles
- Diphenhydramine also called
- benadryl, dph, sleep aid, zzzquil, unisom, doxylamine
- Serotonin Syndrome: Mechanisms, Diagnosis, High-Risk Interactions. https://psychopharmacologyinstitute.com/publication/serotonin-syndrome-mechanisms-diagnosis-high-risk-interactions-and-management/
- Diphenhydramine interaction profile. Drugs.com. https://www.drugs.com/drug-interactions/melatonin.html
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Rated caution. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.