Mixing Cannabis (weed) and Pregabalin (Lyrica)
Low risk, increased effect
Both substances may increase each other's side effects, such as sedation, lowered blood pressure, and raised heart rate.
Can you mix Cannabis (weed) and Pregabalin (Lyrica)?
MixSafe rates mixing Cannabis and Pregabalin as "Low risk, increased effect" — low risk of harm, but the effects amplify each other. Doses that are fine alone can be far too much together. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.
- Cannabis also called
- weed, pot, marijuana, thc, hash, edibles
- Pregabalin also called
- lyrica, pregablin, gabapentin, gaba, neurontin, gabbies
TripSit drug combination chart, retrieved 2026-08-20. View the dataset.
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Checking more than two?
Combinations of three or more carry risks that no pair-by-pair chart can show. The checker rates every pair at once and flags the whole-mix ones on top.
Open this in the checkerRelated combinations
Rated low / synergy. Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety.