Mixing 7-OH and Lithium

Q: How dangerous is 7-OH with Lithium?

Caution: Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

Caution

Together they add sedation, and dehydration can push lithium levels up.

Do this

Keep up water, and keep naloxone nearby.

General answer for Opioids: nothing specific to these two is documented.

Where the risk isTap for why

What “Caution” means

Carries risk that is worth understanding before combining. Reduce doses and do not use alone.

How the ratings work

The longer explanation

No direct pharmacokinetic interaction, but additive sedation and any dehydration or reduced kidney perfusion can raise lithium levels. Note that lithium with tramadol specifically is rated dangerous because of tramadol's serotonergic activity.

Sources (2)

Nayak SM et al., Johns Hopkins, 2021pure.johnshopkins.edu
Ibuprofen interactions to avoid (renal lithium clearance)singlecare.com

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Other names

7-OH: 7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs; Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
Lithium: lithium carbonate, lithobid, mood stabilizer

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Related combinations

7-OH with

What not to mix with 7-OH →

Lithium with

What not to mix with Lithium →

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Can you mix 7-OH and Lithium?

MixSafe rates mixing 7-OH and Lithium as "Caution" — carries risk that is worth understanding before combining. Reduce doses and do not use alone. No interaction specific to 7-OH and Lithium is documented; this is the default for Opioids. Source: MixSafe research. Educational information, not medical advice.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.