Mixing 7-OH and DXM (robo)

Dangerous

Together they slow breathing and strain the heart and liver, and DXM makes the opioid hit harder.

Do this

Do not combine. Keep naloxone nearby.

General answer for Opioids: nothing specific to these two is documented.

Where the risk isTap for why
In an emergency, call 911911Never Use AlonePoison Control
What to do
  • Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
  • Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
  • Give naloxone (Narcan) if you have it.It is sold over the counter in every US state and does no harm if opioids turn out not to be involved.
  • Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
  • Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
  • Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Dangerous” means

High risk of death or life-changing injury. Do not combine.

How the ratings work
The longer explanation

CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.

Sources (1)

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Other names
7-OH
7-hydroxymitragynine, 7-hydroxy mitragynine, 7-hydroxy, 7-oh tablets, 7oh tabs
Concentrated kratom alkaloid sold as tablets — without the leaf's ceiling on slowed breathing
DXM
robo, robitussin, robotussin, syrup, dex, cough syrup
Cold medicines often add acetaminophen or an antihistamine — check the label
Also searched as7-oh and robo, 7-oh and robitussin
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Related combinations

7-OH withWhat not to mix with 7-OH →
DXM withWhat not to mix with DXM →
All combinations →

Can you mix 7-OH and DXM (robo)?

MixSafe rates mixing 7-OH and DXM as "Dangerous" — high risk of death or life-changing injury. Do not combine. No interaction specific to 7-OH and DXM is documented; this is the default for Opioids. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Opioids. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.