Substance
What not to mix with DXM
Dissociative
Also calledrobo, robitussin, robotussin, syrup, dex, cough syrup
Summary
DXM is checked against 40 other substances — 15 dangerous, 10 unsafe and 3 caution.
Dangerous
15- DXM and AlcoholBoth substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the…
- DXM and AMTHigh risk of death or life-changing injury. Do not combine.
- DXM and BuprenorphineCNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance…
- DXM and CodeineCNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance…
- DXM and FentanylCNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance…
- DXM and GHB / GBLBoth substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is…
- DXM and LithiumThere is a risk of serotonin syndrome when combining Lithium with DXM.
- DXM and MAOIsHigh risk of serotonin syndrome
- DXM and MDMAHigh risk of death or life-changing injury. Do not combine.
- DXM and MephedroneRisk of serotonin syndrome as both drugs raise serotonin levels. In addition to concerns of high blood pressure and unnecessary strain on the heart…
- DXM and MethadoneCNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance…
- DXM and OpioidsCNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance…
- DXM and PCPHigh risk of death or life-changing injury. Do not combine.
- DXM and SSRIsHigh risk of serotonin syndrome.
- DXM and TramadolHigh risk of death or life-changing injury. Do not combine.
Unsafe
10- DXM and 2C-T-xRisk of serious physical or psychological harm. Not recommended under any circumstances.
- DXM and 5-MeO-xxTLittle information exists about this combination.
- DXM and AmphetaminesBoth substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
- DXM and CocaineBoth substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues
- DXM and DiphenhydramineThe combination is reported to reduce the side effects of each drug and potentiate many of the recreational effects. There is a significant risk of…
- DXM and DOxThe DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also…
- DXM and MethamphetamineBoth substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
- DXM and MXEThere is a risk of serotonin syndrome when combining DXM with MXE, due to DXM and MXE both being SRI’s. MXE and DXM having notable affinities for the…
- DXM and NBOMesRisk of serious physical or psychological harm. Not recommended under any circumstances.
- DXM and PregabalinPregabalin and DXM may increase each other’s effects such as inhibition, dizziness, sedation. At higher doses this can lead to unexpected loss of…
Caution
3- DXM and BenzodiazepinesSmall doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected…
- DXM and CaffeineHigh doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This…
- DXM and KratomBoth are serotonergic and both are sedating at the doses people take them recreationally. Additive nausea and dissociation, with serotonin toxicity…
Low / synergy
8Low / no synergy
4Checking more than one?
This page rates DXM against one substance at a time. Combinations of three or more carry risks that no pair-by-pair list can show — the checker rates every pair at once and flags the whole-mix ones on top.
Open DXM in the checkerOther dissociatives
All combinations →Educational information only, not medical advice. Absence of a documented interaction is not evidence of safety. Combination data from the TripSit drug combination chart, retrieved 2026-08-20.