Mixing DXM (robo) and Methylphenidate (Ritalin)

Unsafe

Both raise heart rate, and panic on this mix has led to serious heart problems.

Do this

Avoid this combination.

General answer for Amphetamines: nothing specific to these two is documented.

Where the risk isTap for why
In an emergency, call 911911Never Use AlonePoison Control
What to do
  • Say what was taken and how much.Responders need it, and in most US states Good Samaritan laws protect both of you from drug possession charges when you call for an overdose.
  • Unresponsive: put them on their side, tilt the head back, and stay until help arrives.Never leave someone alone to “sleep it off”.
  • Never Use Alone 1-800-484-3731Stays on the line and sends help if you stop responding.
  • Full steps: what to do if it is already happeningOverdose signs, the recovery position, what to say on the call, and whether you can be charged for making it.
  • Poison Control 1-800-222-1222Free and 24/7, for “is this bad?” before it becomes an emergency.
What “Unsafe” means

Risk of serious physical or psychological harm. Not recommended under any circumstances.

How the ratings work
The longer explanation

Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.

Sources (1)

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Other names
DXM
robo, robitussin, robotussin, syrup, dex, cough syrup
Cold medicines often add acetaminophen or an antihistamine — check the label
Methylphenidate
ritalin, ritalin la, concerta, focalin, dexmethylphenidate, methylin
Not an amphetamine, but mixes much like one — most answers here are Adderall's
Also searched asrobo and Ritalin, robitussin and Ritalin, robo and ritalin la, robitussin and ritalin la
Add a third substance in the checker

Related combinations

DXM withWhat not to mix with DXM →
Methylphenidate withWhat not to mix with Methylphenidate →
All combinations →

Can you mix DXM (robo) and Methylphenidate (Ritalin)?

MixSafe rates mixing DXM and Methylphenidate as "Unsafe" — risk of serious physical or psychological harm. Not recommended under any circumstances. No interaction specific to DXM and Methylphenidate is documented; this is the default for Amphetamines. Source: TripSit drug combination chart, retrieved 2026-08-20. Educational information, not medical advice.

This is a class-level answer, inherited from Amphetamines. Nothing specific to this exact pair is documented, so treat it as the default for the class rather than a measurement of these two drugs together.